Top 200 Drugs: Most Prescribed Medicines List

The 200 most-prescribed outpatient medicines in the United States (2024 data), ranked by number of prescriptions. Use the list for pharmacology revision. Where a released guide is available, the medicine name and drug class link to it. Also see the pharmacology practice questions.

Rank	Medicine	Drug class guide
1	Atorvastatin	Statins
2	Levothyroxine
3	Metformin
4	Amlodipine
5	Lisinopril	ACE inhibitors
6	Albuterol
7	Losartan
8	Metoprolol
9	Rosuvastatin
10	Omeprazole	Proton pump inhibitors
11	Gabapentin	Antiepileptics, Gabapentinoids and neuropathic pain agents
12	Sertraline
13	Escitalopram	SSRI antidepressants
14	Semaglutide
15	Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate
16	Pantoprazole	Proton pump inhibitors
17	Bupropion
18	Hydrochlorothiazide	Thiazide and thiazide-like diuretics
19	Fluoxetine	SSRI antidepressants
20	Trazodone
21	Montelukast
22	Amoxicillin	Penicillins
23	Fluticasone	Inhaled and intranasal corticosteroids
24	Tamsulosin
25	Apixaban	Direct oral anticoagulants
26	Simvastatin	Statins
27	Insulin Glargine	Insulins
28	Empagliflozin	SGLT2 inhibitors
29	Furosemide
30	Meloxicam	NSAIDs, including COX-2 selective agents
31	Acetaminophen; Hydrocodone
32	Tirzepatide	GLP-1 receptor agonists
33	Methylphenidate	CNS stimulants and ADHD agents
34	Duloxetine	SNRIs and other antidepressants
35	Prednisone	Systemic corticosteroids
36	Carvedilol
37	Famotidine
38	Ibuprofen	NSAIDs, including COX-2 selective agents
39	Buspirone
40	Venlafaxine	SNRIs and other antidepressants
41	Tramadol
42	Potassium Chloride
43	Hydroxyzine	Antihistamines
44	Allopurinol
45	Clopidogrel	Antiplatelet agents
46	Ergocalciferol
47	Cetirizine
48	Ondansetron	Antiemetics
49	Cyclobenzaprine
50	Spironolactone	Mineralocorticoid receptor antagonists, Potassium-sparing diuretics
51	Oxycodone	Opioid analgesics
52	Estradiol	Sex hormones and hormonal contraceptives
53	Aspirin
54	Glipizide	Sulfonylureas
55	Zolpidem
56	Lamotrigine	Antiepileptics, Mood stabilisers
57	Alprazolam	Benzodiazepines
58	Citalopram	SSRI antidepressants
59	Pregabalin	Gabapentinoids and neuropathic pain agents
60	Cholecalciferol
61	Clonazepam	Benzodiazepines
62	Azithromycin	Macrolides
63	Pravastatin
64	Valsartan
65	Ezetimibe	Cholesterol absorption inhibitors
66	Diclofenac	NSAIDs, including COX-2 selective agents
67	Insulin Lispro	Insulins
68	Ethinyl Estradiol; Norethindrone
69	Propranolol
70	Latanoprost
71	Atenolol	Beta blockers
72	Lisdexamfetamine
73	Doxycycline
74	Amoxicillin; Clavulanate
75	Dulaglutide
76	Hydrochlorothiazide; Lisinopril
77	Lorazepam	Benzodiazepines
78	Fluticasone; Salmeterol
79	Insulin Aspart	Insulins
80	Celecoxib	NSAIDs, including COX-2 selective agents
81	Finasteride
82	Quetiapine
83	Clonidine
84	Aripiprazole	Atypical antipsychotics, Mood stabilisers
85	Cephalexin	Cephalosporins
86	Alendronate
87	Topiramate	Antiepileptics, Triptans and migraine agents
88	Tizanidine
89	Dapagliflozin	SGLT2 inhibitors
90	Acetaminophen; Oxycodone
91	Hydrochlorothiazide; Losartan
92	Olmesartan
93	Testosterone
94	Amitriptyline
95	Folic Acid
96	Rivaroxaban	Direct oral anticoagulants
97	Fenofibrate
98	Triamcinolone
99	Paroxetine	SSRI antidepressants
100	Ferrous Sulfate
101	Loratadine	Antihistamines
102	Warfarin
103	Valacyclovir	Antiherpes antivirals
104	Budesonide; Formoterol
105	Ethinyl Estradiol; Norgestimate
106	Fluticasone; Umeclidinium; Vilanterol
107	Methocarbamol
108	Acetaminophen	Paracetamol and other non-opioid analgesics
109	Diltiazem
110	Thyroid
111	Baclofen
112	Naproxen	NSAIDs, including COX-2 selective agents
113	Sumatriptan
114	Prednisolone	Systemic corticosteroids
115	Esomeprazole	Proton pump inhibitors
116	Mirtazapine	SNRIs and other antidepressants
117	Levetiracetam	Antiepileptics
118	Norethindrone
119	Tadalafil
120	Nifedipine	Dihydropyridine calcium channel blockers
121	Progesterone
122	Insulin Degludec	Insulins
123	Cyanocobalamin
124	Hydralazine
125	Adalimumab	Biologic DMARDs
126	Azelastine
127	Sitagliptin	DPP-4 inhibitors
128	Glimepiride	Sulfonylureas
129	Chlorthalidone
130	Oxybutynin
131	Pioglitazone
132	Ketoconazole
133	Irbesartan	Angiotensin receptor blockers
134	Hydroxychloroquine
135	Sulfamethoxazole; Trimethoprim
136	Benzonatate
137	Nitrofurantoin
138	Isosorbide
139	Methylprednisolone	Systemic corticosteroids
140	Hydrochlorothiazide; Triamterene
141	Levocetirizine
142	Clindamycin	Lincosamides
143	Atomoxetine
144	Dexmethylphenidate
145	Methotrexate	Conventional DMARDs
146	Donepezil
147	Desvenlafaxine	SNRIs and other antidepressants
148	Ropinirole	Antiparkinsonian agents
149	Clobetasol
150	Fluticasone; Vilanterol
151	Albuterol; Ipratropium
152	Phentermine
153	Ofloxacin	Fluoroquinolones
154	Mupirocin	Mupirocin
155	Verapamil
156	Olanzapine	Atypical antipsychotics, Mood stabilisers
157	Metronidazole	Metronidazole & the Nitroimidazoles
158	Prazosin
159	Ciprofloxacin	Fluoroquinolones
160	Sildenafil
161	Ethinyl Estradiol; Levonorgestrel
162	Evolocumab	PCSK9 inhibitors
163	Mesalamine
164	Memantine
165	Ethinyl Estradiol; Etonogestrel
166	Diazepam	Benzodiazepines
167	Lithium
168	Nortriptyline
169	Timolol
170	Cefdinir	Cephalosporins
171	Magnesium Salts
172	Meclizine
173	Cyclosporine
174	Fluconazole	Azole antifungals
175	Rimegepant	Triptans and migraine agents
176	Tretinoin
177	Lovastatin	Statins
178	Drospirenone; Ethinyl Estradiol
179	Tiotropium
180	Docusate	Laxatives and antidiarrhoeals
181	Temazepam	Benzodiazepines, Z-drugs and other hypnotics
182	Benazepril
183	Brimonidine
184	Sacubitril; Valsartan
185	Valproate
186	Nebivolol	Beta blockers
187	Acyclovir
188	Morphine
189	Doxazosin	Alpha blockers
190	Amlodipine; Benazepril
191	Nirmatrelvir; Ritonavir
192	Emtricitabine; Tenofovir
193	Budesonide
194	Tacrolimus	Calcineurin inhibitors
195	Dupilumab
196	Enalapril	ACE inhibitors
197	Anastrozole
198	Melatonin	Z-drugs and other hypnotics
199	Torsemide
200	Polyethylene Glycol 3350

Rankings adapted from ClinCalc DrugStats: Top 200 Drugs of 2024, accessed 2026-09-28, under CC BY-SA 4.0. Rankings reflect US prescribing and differ in other countries.