Yttrium (Yttrium (commonly as Yttrium-90 or Yttrium chloride)) — Uses, Dosage, Side Effects & Safety

Drug class: Radiopharmaceutical, Antineoplastic Agent

Overview

Yttrium, most commonly used as the radioactive isotope Yttrium-90, is a specialized medicine used in cancer treatment, particularly for certain types of liver cancer and lymphomas. It is administered directly into the blood vessels supplying a tumor or as part of a radiolabeled antibody therapy. Yttrium-90 works by delivering targeted radiation to cancer cells, helping to shrink or destroy tumors while minimizing damage to surrounding healthy tissue. This targeted approach can be especially helpful for patients who are not candidates for surgery or other systemic therapies. Key points for patients: Yttrium-based therapies are given in a hospital or clinic setting by trained specialists. The treatment is highly individualized, and your healthcare team will monitor you closely for side effects and effectiveness.

Therapeutic uses

  • Treatment of unresectable hepatocellular carcinoma (HCC)
  • Treatment of metastatic colorectal cancer (mCRC) to the liver
  • Treatment of non-Hodgkin lymphoma (NHL)
  • Radiosynovectomy for chronic synovitis (e.g., rheumatoid arthritis, psoriatic arthritis)

For related Yttrium guidance, compare Xofigo and Radium 223 dichloride.

Common side effects

  • Fatigue
  • Nausea
  • Vomiting
  • Abdominal pain
  • Myelosuppression
  • Fever
  • Diarrhea

Frequently Asked Questions about Yttrium

What is Yttrium-90 used for?

Yttrium-90 is primarily used to treat certain liver cancers (such as hepatocellular carcinoma and metastatic colorectal cancer) and as part of radioimmunotherapy for some lymphomas.

How is Yttrium-90 administered?

It is administered by a specialist as an intra-arterial injection (microspheres) or as part of a radiolabeled antibody infusion, usually in a hospital or clinic.

What should I expect after Yttrium-90 treatment?

You may experience mild side effects like fatigue, mild pain, or nausea. Your healthcare team will monitor you for any serious reactions.

Is Yttrium-90 safe during pregnancy?

No, Yttrium-90 is not recommended during pregnancy due to the risk of fetal harm from radiation.

Can I be around others after treatment?

You may need to limit close contact with pregnant women and young children for a short period after treatment. Your doctor will provide specific guidance.

Are there long-term risks with Yttrium-90?

Long-term risks may include liver damage or radiation-induced changes. Regular follow-up is important to monitor for late effects.

What should I do if I feel unwell after treatment?

Contact your healthcare provider immediately if you experience severe pain, jaundice, fever, or any symptoms listed in the warning signs.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.