Xofigo (Radium Ra 223 dichloride) — Uses, Dosage, Side Effects & Safety

Drug class: Radiopharmaceutical, Antineoplastic Agent

Overview

Xofigo is a prescription medicine used to treat adults with prostate cancer that has spread to the bones (bone metastases) and is resistant to medical or surgical treatments that lower testosterone (castration-resistant prostate cancer). It is not used for cancers that have spread to organs other than the bones. Xofigo contains radium-223, a radioactive substance that targets bone metastases. It works by mimicking calcium and binding to areas of increased bone turnover, delivering targeted radiation to cancer cells in the bone while minimizing damage to surrounding healthy tissue. Key points for patients: Xofigo is given as an intravenous injection by a healthcare professional, typically every 4 weeks for up to 6 doses. It can help reduce bone pain and delay complications from bone metastases. Regular blood tests are needed to monitor for side effects.

Therapeutic uses

  • Treatment of patients with castration-resistant prostate cancer
  • Treatment of patients with symptomatic bone metastases
  • Treatment of patients with no known visceral metastatic disease

For related Xofigo guidance, compare Yttrium and Radium 223 dichloride.

Common side effects

  • Nausea
  • Diarrhea
  • Vomiting
  • Thrombocytopenia
  • Anemia
  • Neutropenia
  • Peripheral edema
  • Bone marrow suppression

Frequently Asked Questions about Xofigo

What is Xofigo used for?

Xofigo is used to treat men with prostate cancer that has spread to the bones and is resistant to treatments that lower testosterone. It helps manage bone pain and delays bone complications.

How is Xofigo administered?

Xofigo is given as a slow intravenous injection by a healthcare professional, usually every 4 weeks for up to 6 doses.

What are the most common side effects of Xofigo?

The most common side effects are nausea, diarrhea, vomiting, swelling, and low blood cell counts. Serious side effects include infections and bleeding.

Can women take Xofigo?

No, Xofigo is not indicated for use in women, especially those who are pregnant or breastfeeding, due to the risk of fetal harm.

What should I do if I miss a dose?

Contact your healthcare provider to reschedule the missed dose. Do not attempt to take the medication yourself.

Are there any special precautions after receiving Xofigo?

Yes, you should follow radiation safety instructions provided by your healthcare team, including hygiene measures and limiting close contact with pregnant women and children for a few days after each injection.

Does Xofigo cure prostate cancer?

Xofigo does not cure prostate cancer but can help manage symptoms and delay complications from bone metastases.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.