Ubrogepant
Pronunciation: (yoo-broe-GEH-pant).
- Generic name
- ubrogepant
- Brand names
- Ubrelvy, Migraub, Ubrocap
- Drug class
- Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist
Prescription_only
Trade names by country: United States
United States: UBRELVY · Full directory
What ubrogepant is and how it works
Uses, formulations, monitoring, and supply rules can differ by patient, product, and country. Follow the exact local product information and professional advice.
Mechanism of action: how ubrogepant works
Ubrogepant is a selective, oral calcitonin gene-related peptide (CGRP) receptor antagonist. CGRP is a neuropeptide involved in the pathophysiology of migraine, mediating vasodilation and pain transmission. By blocking the CGRP receptor, ubrogepant inhibits the binding of CGRP, thereby reducing neurogenic inflammation and pain signaling associated with migraine attacks. (1) (2)
What ubrogepant is used for
Acute treatment of migraine with or without aura
Acute treatment of migraine with or without aura
Before taking ubrogepant
Do not take / not appropriate for
- Contraindicated in patients with known hypersensitivity to ubrogepant or any component of the formulation, and in those with severe hepatic impairment (Child-Pugh C). (Contraindication)
Tell your clinician about
How to take ubrogepant
- General Instructions: Take ubrogepant exactly as prescribed by your healthcare provider. It is intended for use at the onset of a migraine attack, not for prevention.. Adult Dosing: The recommended starting dose is 50 mg or 100 mg taken orally as needed for migraine. A second dose may be taken at least 2 hours after the first dose if needed. Do not exceed 200 mg in 24 hours.. Pediatric Dosing: Safety and efficacy in pediatric patients have not been established. Ubrogepant is not recommended for use in children.. Administration: Take the tablet by mouth with or without food. Swallow whole with water.. When To Seek Review: Contact your healthcare provider promptly if you experience signs of an allergic reaction or liver problems. Your healthcare provider will advise whether to continue or stop treatment.. Storage: Store at room temperature (20°C to 25°C/68°F to 77°F), away from moisture and heat.
- This page does not provide a dose calculator. Dosing must follow the prescriber, pharmacist, or product label.
Procedures and treatment changes
Tell the treating team before surgery, procedures, or any medicine change. Do not alter treatment without the responsible clinician.
Missed dose
Ubrogepant is taken as needed for migraine attacks. If you miss a dose during an attack, take it as soon as possible. Do not take more than the recommended dose in 24 hours.
Overdose
If you or someone else has taken too much ubrogepant, seek emergency medical attention or contact a poison control center immediately. Symptoms of overdose may include severe drowsiness, nausea, or other serious effects.
Side effects
Side effects and their urgency vary; report severe, persistent, or concerning symptoms to a healthcare professional.
Nausea
Incidence: Reported in the clinician-authored database; frequency not established
Somnolence
Incidence: Reported in the clinician-authored database; frequency not established
Dry mouth
Incidence: Reported in the clinician-authored database; frequency not established
Fatigue
Incidence: Reported in the clinician-authored database; frequency not established
Abdominal pain
Incidence: Reported in the clinician-authored database; frequency not established
Vomiting
Incidence: Reported in the clinician-authored database; frequency not established
Hypersensitivity reactions
Incidence: Reported in the clinician-authored database; frequency not established
Serious warnings
May cause liver enzyme elevations — serious
Symptoms: May cause liver enzyme elevations; monitor for signs of liver dysfunction. Not for prevention of migraine attacks. Do not use in severe hepatic impairment. Potential for drug interactions with CYP3A4 inhibitors/inducers. Use caution in patients with moderate or severe renal impairment.
Action: Follow the urgency stated and seek prompt or emergency care when indicated.
Contraindications recorded in the clinician database — serious
Symptoms: Contraindications recorded in the clinician database: Contraindicated in patients with known hypersensitivity to ubrogepant or any component of the formulation, and in those with severe hepatic impairment (Child-Pugh C). Use caution in patients with moderate hepatic or severe renal impairment. Monitor for signs of liver dysfunction.
Action: Follow the urgency stated and seek prompt or emergency care when indicated.
Interactions
| Medicine or test | Effect | Action |
|---|---|---|
| Recorded interactions | Ubrogepant is metabolized by the CYP3A4 enzyme. Strong CYP3A4 inhibitors (such as ketoconazole, clarithromycin) can increase ubrogepant levels and should be avoided. Dose adjustments may be required with moderate CYP3A4 inhibitors. Avoid use with strong CYP3A4 inducers (such as rifampin), as they may decrease effectiveness. Always inform your healthcare provider about all medications and supplements you are taking. | (1) |
Pregnancy, breastfeeding, kidney/liver function, age
Pregnancy
Requires a primary-source research pass before this section can be completed.
Breastfeeding
Requires a primary-source research pass before this section can be completed.
Children
Frequency: Not applicable. Weight Based: Not recommended for pediatric use. Max Daily Dose: Not applicable. Max Single Dose: Not applicable. Age Restrictions: Safety not established in children
Renal_impairment
Requires a primary-source research pass before this section can be completed.
Hepatic_impairment
Requires a primary-source research pass before this section can be completed.
Monitoring
Storage
Requires a primary-source research pass before this section can be completed.
Study the drug class: Triptans and migraine agents
Professional information
Clinician-facing context only. This section does not replace current product labeling.
General
Indication: Acute treatment of migraine with or without aura
Dose summary: Initial dose of 50 mg or 100 mg taken orally as needed for the acute treatment of migraine.
Renal context: No dose adjustment is recommended in mild or moderate renal impairment. In severe renal impairment (creatinine clearance 15 to 29 mL/min) use 50 mg as the initial dose and 50 mg if a second dose is needed. Avoid use in end-stage renal disease (creatinine clearance below 15 mL/min). (1) (2)
Hepatic guidance
No dose adjustment is recommended in mild or moderate hepatic impairment. In severe hepatic impairment (Child-Pugh C) use 50 mg initially and 50 mg for a second dose if needed. Ubrogepant exposure increased by 7%, 50% and 115% in mild, moderate and severe hepatic impairment respectively.
Frequently asked questions
What is Ubrelvy?
Ubrelvy (ubrogepant) is a prescription medicine belonging to the "gepant" class (CGRP receptor antagonist). It is used for the acute (as-it-happens) treatment of migraine attacks with or without aura in adults. It is NOT for preventing migraines.
What is Ubrelvy used for?
Acute treatment of migraine attacks (with or without aura) in adults. It is taken only when you have a migraine — not daily or for prevention.
Is Ubrelvy for acute or preventive treatment?
Acute treatment only. You take it at the first sign of a migraine. It is not a preventive (prophylactic) medicine.
How does Ubrelvy work?
Ubrelvy blocks calcitonin gene-related peptide (CGRP) receptors in the brain. CGRP is a protein that causes inflammation and pain during a migraine attack.
What are the common side effects of Ubrelvy?
Most common (≥2%): Nausea, Sleepiness/drowsiness/tiredness, Dry mouth. These are usually mild and go away quickly.
Does Ubrelvy make you sleepy?
Yes — sleepiness or drowsiness is the second most common side effect (2–6% of patients). Do not drive or operate machinery until you know how it affects you.
How should Ubrelvy be taken?
Starting dose: 50 mg or 100 mg by mouth as soon as migraine symptoms start. A second dose (50 mg or 100 mg) may be taken at least 2 hours later if needed. Maximum: 200 mg in 24 hours. Do not take more than 8 doses in 30 days.
Can you take a second dose of Ubrelvy?
Yes — if the migraine returns or does not fully improve after 2 hours, you can take a second dose (up to 200 mg total per day).
What happens if you take Ubrelvy without a migraine?
It is not recommended. Taking it when you do not have a migraine will not prevent one and may increase side effects.
Does Ubrelvy help with nausea or tension headaches?
It is only proven for migraine (with or without aura). It may help nausea that comes with migraine, but it is not approved for tension-type headaches or vestibular migraine specifically.
Can you take Tylenol or ibuprofen with Ubrelvy?
Yes — no known interactions with acetaminophen (Tylenol), ibuprofen, or most common pain relievers. Many patients combine them safely.
What drugs interact with Ubrelvy?
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin) can increase Ubrelvy levels — dose must be reduced or avoided. Avoid with strong CYP3A4 inducers long-term (they make Ubrelvy less effective).
Is Ubrelvy a narcotic or triptan?
No — it is neither a triptan nor a narcotic/opioid. It is a CGRP antagonist (gepant) and is not habit-forming.
Is Ubrelvy safe during breastfeeding or pregnancy?
Limited data. Talk to your doctor — it is not recommended during breastfeeding; use only if clearly needed in pregnancy.
What is the generic name for Ubrelvy?
Generic name: ubrogepant. Brand name: Ubrelvy (made by AbbVie/Allergan). No generic is available yet in most countries as of November 2025.
How quickly does Ubrelvy work?
Many patients feel relief within 1–2 hours; some as fast as 30–60 minutes.
What is Ubrelvy? / Ubrelvy what is it / What kind of medication is Ubrelvy?
Ubrelvy (ubrogepant) is a prescription medicine belonging to the 'gepant' class (CGRP receptor antagonist). It is used for the acute (as-it-happens) treatment of migraine attacks with or without aura in adults. It is NOT for preventing migraines.
What is Ubrelvy used for? / Ubrelvy treats / What's Ubrelvy used for?
Acute treatment of migraine attacks (with or without aura) in adults. It is taken only when you have a migraine — not daily or for prevention.
Is Ubrelvy for acute or preventive treatment? / Is Ubrelvy acute or preventive? / Is Ubrelvy a daily medication?
Acute treatment only. You take it at the first sign of a migraine. It is not a preventive (prophylactic) medicine.
How does Ubrelvy work? / Ubrelvy how does it work / What does Ubrelvy do?
Ubrelvy blocks calcitonin gene-related peptide (CGRP) receptors in the brain. CGRP is a protein that causes inflammation and pain during a migraine attack.
What are the common side effects of Ubrelvy? / Ubrelvy side effects / Side effects of Ubrelvy / Ubrelvy 50 mg side effects
Most common (≥2%): Nausea, Sleepiness/drowsiness/tiredness, Dry mouth. These are usually mild and go away quickly.
Does Ubrelvy make you sleepy? / Can Ubrelvy make you sleepy? / Ubrelvy insomnia
Yes — sleepiness or drowsiness is the second most common side effect (2–6% of patients). Do not drive or operate machinery until you know how it affects you. (Note: a few patients report the opposite — difficulty sleeping — but drowsiness is far more common.)
How should Ubrelvy be taken? / Ubrelvy dosage instructions / Ubrelvy usage / Max dose Ubrelvy
Starting dose: 50 mg or 100 mg by mouth as soon as migraine symptoms start. A second dose (50 mg or 100 mg) may be taken at least 2 hours later if needed. Maximum: 200 mg in 24 hours. Do not take more than 8 doses in 30 days (to avoid medication-overuse headache risk).
Does Ubrelvy help with nausea or tension headaches? / Ubrelvy vestibular migraine / Can Ubrelvy help with tension headaches?
It is only proven for migraine (with or without aura). It may help nausea that comes with migraine, but it is not approved for tension-type headaches or vestibular migraine specifically.
Can you take Tylenol or ibuprofen with Ubrelvy? / Lexapro and Ubrelvy / Can you take ibuprofen and Ubrelvy / Ubrelvy and Excedrin Migraine
Yes — no known interactions with acetaminophen (Tylenol), ibuprofen, or most common pain relievers. Many patients combine them safely.
Is Ubrelvy a narcotic or triptan? / Ubrelvy a narcotic?
No — it is neither a triptan nor a narcotic/opioid. It is a CGRP antagonist (gepant) and is not habit-forming.
Is Ubrelvy safe during breastfeeding or pregnancy? / Ubrelvy breastfeeding
Limited data. Talk to your doctor — it is not recommended during breastfeeding; use only if clearly needed in pregnancy.
What is the generic name for Ubrelvy? / Ubrelvy other names / Ubrelvy other name
Generic name: ubrogepant. Brand name: Ubrelvy (made by AbbVie/Allergan). No generic is available yet in most countries as of November 2025.
How quickly does Ubrelvy work? / Does Ubrelvy work?
Many patients feel relief within 1–2 hours; some as fast as 30–60 minutes.
What happens if I take too much Ubrogepant (Ubrelvy)?
Taking too much Ubrogepant (Ubrelvy) can potentially lead to an increase in common side effects such as nausea, somnolence, or dry mouth. While specific severe overdose symptoms are not well-documented, it is crucial to seek emergency medical attention immediately if an overdose is suspected. Always adhere to your prescribed dosage to ensure safety and effectiveness.
Can I drink alcohol while taking Ubrogepant (Ubrelvy)?
It is generally advisable to exercise caution or avoid alcohol consumption while taking Ubrogepant (Ubrelvy). Alcohol can exacerbate common migraine symptoms and may also intensify certain side effects of Ubrogepant, such as nausea or dizziness. Discuss your alcohol intake with your healthcare provider to understand potential risks and receive personalized guidance.
Is Ubrogepant (Ubrelvy) safe during pregnancy?
The safety of Ubrogepant (Ubrelvy) during pregnancy has not been definitively established. It is categorized as 'Consult doctor' regarding pregnancy. If you are pregnant, planning to become pregnant, or breastfeeding, it is essential to consult your healthcare provider before using Ubrogepant. They can assess the potential risks and benefits and recommend the most appropriate treatment plan for your situation.
What is the mechanism of action of ubrogepant?
Ubrogepant is a selective, oral calcitonin gene-related peptide (CGRP) receptor antagonist. CGRP is a neuropeptide involved in the pathophysiology of migraine, mediating vasodilation and pain transmission. By blocking the CGRP receptor, ubrogepant inhibits the binding of CGRP, thereby reducing neurogenic inflammation and pain signaling associated with migraine attacks. (1) (2)
What is the generic name of Ubrogepant?
The generic name is ubrogepant. It is sold under brand names including Ubrelvy, Migraub, Ubrocap.
What class of drug is ubrogepant?
Ubrogepant is classed as: Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist.
References
- UBRELVY (ubrogepant) tablets — prescribing informationU.S. Food and Drug Administration · United States · dated 2025 · accessed 2026-07-22 · source 1
- Ubrogepant Drug InformationMedlinePlus, U.S. National Library of Medicine · United States · accessed 2026-07-22 · source 2
- UBRELVY (UBROGEPANT) TABLET [ALLERGAN, INC.] — US prescribing information (DailyMed SPL)U.S. National Library of Medicine (DailyMed) · US · accessed 2026-08-14 · source 3
- Ubrogepant — patient drug information (MedlinePlus)U.S. National Library of Medicine (MedlinePlus) · US · accessed 2026-08-14 · source 4
- UBRELVY — FDA approval record (Drugs@FDA NDA211765)U.S. Food and Drug Administration · US · accessed 2026-08-14 · source 5
- ubrogepant — RxNorm normalized drug concept (RXCUI 2268216)U.S. National Library of Medicine (RxNorm) · US · accessed 2026-08-14 · source 6
Brand names by country
Single-ingredient ubrogepant names are shown separately by country. Product availability, strengths, and supply rules can change; combination products are not included here.
Priority countries
United States
- UBRELVY50 mg, 100 mg · allergan, inc.