Temozolomide (temozolomide) — Uses, Dosage, Side Effects & Safety

Drug class: Alkylating agent (antineoplastic, chemotherapy)

Overview

Temozolomide is a prescription chemotherapy medicine used to treat certain types of brain tumors, including newly diagnosed glioblastoma multiforme and refractory anaplastic astrocytoma. It is often used in combination with radiotherapy or as a single agent in adults and children. Temozolomide works by interfering with the DNA of cancer cells, preventing them from growing and multiplying. This helps slow or stop the spread of cancer in the brain. Key points for patients: Temozolomide is usually taken once daily, with or without food, and dosing is based on your body size and treatment plan. It is important to take the medication exactly as prescribed and to report any unusual symptoms to your healthcare provider.

Therapeutic uses

  • Glioblastoma multiforme (GBM)
  • Anaplastic astrocytoma
  • Other anaplastic gliomas
  • Refractory anaplastic astrocytoma

For related Temozolomide guidance, compare Ifosfamide, Thiotepa and Melphalan.

Common side effects

  • Nausea
  • Vomiting
  • Fatigue
  • Headache
  • Myelosuppression
  • Constipation
  • Alopecia

Frequently Asked Questions about Temozolomide

What is temozolomide used for?

Temozolomide is used to treat certain brain tumors, including glioblastoma multiforme and anaplastic astrocytoma, in adults and children.

How does temozolomide work?

Temozolomide works by damaging the DNA of cancer cells, which prevents them from growing and dividing.

What are the most common side effects?

The most common side effects are nausea, vomiting, fatigue, constipation, headache, and loss of appetite.

Can I take temozolomide during pregnancy?

No. Temozolomide can harm an unborn baby. Use effective contraception during treatment and for at least 6 months after the last dose.

What should I do if I miss a dose?

Take the missed dose as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose. Do not double up doses.

How is temozolomide given?

Temozolomide is usually taken by mouth as a capsule, once daily, with or without food. It should be swallowed whole with water.

Are there any foods or medicines I should avoid?

Avoid live vaccines and contact with people who have infections. Always inform your doctor about all medicines and supplements you are taking.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.