Ifosfamide (ifosfamide) — Uses, Dosage, Side Effects & Safety

Drug class: Alkylating agent (antineoplastic, chemotherapy)

Overview

Ifosfamide is a chemotherapy medication used to treat various types of cancer, including testicular cancer, sarcomas, lymphomas, and some solid tumors. It works by interfering with the DNA of cancer cells, preventing them from growing and multiplying. This medicine is usually given in a hospital or clinic setting by a healthcare professional as an intravenous (IV) infusion. Patients may receive ifosfamide alone or in combination with other cancer medicines. Because it can affect both cancerous and healthy cells, close monitoring is required during treatment. Key points for patients: Ifosfamide can cause side effects such as nausea, hair loss, and increased risk of infection. It is important to attend all scheduled appointments and report any unusual symptoms to your doctor promptly.

Therapeutic uses

• Germ cell testicular cancer
• Sarcoma (soft tissue and bone)
• Lymphoma (non-Hodgkin's and Hodgkin's)
• Lung cancer (small cell)
• Breast cancer

For related Ifosfamide guidance, compare Thiotepa, Melphalan and Temozolomide.

Common side effects

• Bone marrow suppression
• Hemorrhagic cystitis
• Neurotoxicity (encephalopathy)
• Nausea and vomiting
• Alopecia
• Kidney damage
• Infections

Frequently Asked Questions about Ifosfamide

What types of cancer is ifosfamide used to treat?

Ifosfamide is primarily used to treat testicular cancer, sarcomas (soft tissue and bone), lymphomas, and certain other solid tumors. It may be used alone or in combination with other chemotherapy drugs.

How is ifosfamide administered?

Ifosfamide is given as an intravenous infusion by a healthcare professional, usually in a hospital or clinic setting. It is not available as a tablet or oral medication.

What are the most serious side effects of ifosfamide?

Serious side effects include bone marrow suppression, hemorrhagic cystitis (bladder bleeding), neurotoxicity (confusion, seizures), kidney damage, and increased risk of infection.

Why is mesna given with ifosfamide?

Mesna is co-administered to protect the bladder from toxic metabolites of ifosfamide, reducing the risk of hemorrhagic cystitis.

Can ifosfamide affect fertility?

Yes, ifosfamide can cause temporary or permanent infertility in both men and women. Discuss fertility preservation options with your doctor before starting treatment.

What should I do if I develop blood in my urine during treatment?

Contact your healthcare provider immediately if you notice blood in your urine, as this may indicate bladder toxicity and requires prompt medical attention.

Is ifosfamide safe during pregnancy or breastfeeding?

Ifosfamide is not safe during pregnancy or breastfeeding due to the risk of birth defects and harm to the baby. Effective contraception is recommended during and after treatment.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.