Glecaprevir + Pibrentasvir (Mavyret) (glecaprevir and pibrentasvir) — Uses, Dosage, Side Effects & Safety

Drug class: Infectious & Communicable Diseases

Overview

Glecaprevir + Pibrentasvir (brand name: Mavyret/Maviret) is a prescription medicine used to treat chronic hepatitis C virus (HCV) infection in adults and children 3 years of age and older. It is effective against all major genotypes (types 1-6) of HCV. This medication works by blocking two proteins (NS3/4A protease and NS5A) that the hepatitis C virus needs to multiply. By stopping the virus from reproducing, it helps clear the infection from your body. Key points: Treatment is usually short (8-16 weeks), does not require interferon or ribavirin, and is highly effective. It is important to take the medication exactly as prescribed and complete the full course, even if you feel well.

Therapeutic uses

  • Chronic hepatitis C virus (HCV) genotype 1 infection
  • Chronic hepatitis C virus (HCV) genotype 2 infection
  • Chronic hepatitis C virus (HCV) genotype 3 infection
  • Chronic hepatitis C virus (HCV) genotype 4 infection
  • Chronic hepatitis C virus (HCV) genotype 5 and 6 infection

For related Glecaprevir + Pibrentasvir (Mavyret) guidance, compare Lopinavir, Valganciclovir and Sofosbuvir/Ledipasvir.

Common side effects

  • Headache
  • Nausea
  • Diarrhea
  • Fatigue
  • Elevated liver enzymes
  • Severe skin reactions
  • Hepatitis B reactivation

Frequently Asked Questions about Glecaprevir + Pibrentasvir (Mavyret)

How effective is Glecaprevir + Pibrentasvir (Mavyret) for hepatitis C?

Clinical studies show cure rates (sustained virologic response) above 95% for most hepatitis C genotypes when taken as prescribed.

Can I take this medicine if I have cirrhosis?

It can be used in patients with compensated cirrhosis (Child-Pugh A), but is not recommended for those with decompensated cirrhosis (Child-Pugh B or C).

Is it safe during pregnancy or breastfeeding?

There is limited data on use in pregnancy and breastfeeding. Discuss risks and benefits with your doctor.

Do I need to adjust my diet while taking this medicine?

No special diet is required, but always take the tablets with food to improve absorption.

What should I do if I vomit after taking a dose?

If you vomit within 3 hours of taking a dose, take another dose. If more than 3 hours have passed, wait until your next scheduled dose.

Can I drink alcohol while on this medication?

Alcohol can worsen liver damage. It is best to avoid alcohol during hepatitis C treatment.

Will this medicine cure hepatitis C permanently?

If you complete the full course and achieve a sustained virologic response (SVR), hepatitis C is considered cured. However, you can be reinfected if exposed again.

Related Glecaprevir + Pibrentasvir (Mavyret) information

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.