Glasdegib — Uses, Dosage, Side Effects & Safety

Drug class: Hedgehog pathway inhibitor; Antineoplastic agent

Overview

Glasdegib is a prescription medication used to treat newly diagnosed acute myeloid leukemia (AML) in adults who are 75 years or older, or who have health conditions that prevent them from receiving intensive chemotherapy. It is typically used in combination with low-dose cytarabine. Glasdegib works by blocking a specific signaling pathway (the Hedgehog pathway) that cancer cells use to grow and survive. By inhibiting this pathway, glasdegib helps slow down or stop the growth of leukemia cells. Key points for patients: Take glasdegib exactly as prescribed, usually once daily. Regular blood tests are needed to monitor for side effects. Inform your healthcare provider about all other medications and supplements you are taking.

Therapeutic uses

  • Treatment of newly diagnosed acute myeloid leukemia (AML) with de novo or secondary AML in adult patients who are not candidates for intensive induction chemotherapy due to comorbidities.
  • Treatment of newly diagnosed acute myeloid leukemia (AML) with de novo or secondary AML in adult patients who are not candidates for intensive induction chemotherapy due to age.
  • Inhibition of the Hedgehog signaling pathway in cancer.

Common side effects

  • Muscle spasms
  • Nausea
  • Fatigue
  • Hair loss
  • Decreased appetite
  • Weight loss
  • Anemia
  • QT prolongation

Frequently Asked Questions about Glasdegib

What is glasdegib used for?

Glasdegib is used in combination with low-dose cytarabine to treat newly diagnosed acute myeloid leukemia (AML) in adults who are not eligible for intensive chemotherapy.

How does glasdegib work?

Glasdegib blocks the Hedgehog signaling pathway, which is involved in the growth and survival of certain cancer cells. By inhibiting this pathway, it helps slow or stop the progression of leukemia.

What are the most common side effects of glasdegib?

Common side effects include nausea, vomiting, decreased appetite, fatigue, muscle pain, and changes in taste.

Can glasdegib be used in children?

No, glasdegib is not approved for use in children or adolescents under 18 years of age.

Are there any foods or drugs I should avoid while taking glasdegib?

Avoid grapefruit and grapefruit juice, and do not take glasdegib with strong CYP3A4 inhibitors or inducers unless directed by your doctor.

What should I do if I miss a dose?

Take the missed dose as soon as you remember on the same day. If it is the next day, skip the missed dose and continue your regular schedule. Do not double up doses.

Is glasdegib safe during pregnancy?

No, glasdegib can cause harm to an unborn baby. Effective contraception is required during treatment and for at least 30 days after the last dose.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.