Glecaprevir — Uses, Dosage, Side Effects & Safety

Drug class: Antiviral (Hepatitis C Virus NS3/4A Protease Inhibitor)

Overview

Glecaprevir is an antiviral medication used in combination with pibrentasvir to treat chronic hepatitis C virus (HCV) infection in adults and children aged 3 years and older. It is effective against all major HCV genotypes (1-6), making it a pan-genotypic therapy. Glecaprevir works by blocking a key enzyme (NS3/4A protease) that the hepatitis C virus needs to multiply. By stopping the virus from replicating, it helps clear the infection from the body. Key points for patients: Treatment is usually short (8-16 weeks), and most people experience few side effects. It is important to take the medication exactly as prescribed and complete the full course, even if you feel well.

Therapeutic uses

  • Chronic Hepatitis C Virus (HCV) infection (genotypes 1-6)
  • HCV infection in patients with compensated cirrhosis
  • HCV infection in patients with severe renal impairment (including those on dialysis)
  • HCV infection in patients who have failed previous direct-acting antiviral (DAA) therapy

Common side effects

  • Headache
  • Nausea
  • Diarrhea
  • Fatigue
  • Increased liver enzymes
  • Rash
  • Anemia

Frequently Asked Questions about Glecaprevir

What is glecaprevir used for?

Glecaprevir, in combination with pibrentasvir, is used to treat chronic hepatitis C infection in adults and children aged 3 years and older. It is effective against all major HCV genotypes.

How long do I need to take glecaprevir?

Treatment duration is typically 8 to 16 weeks, depending on your hepatitis C genotype and previous treatment history. Your doctor will determine the exact length.

Can I take glecaprevir if I have liver problems?

Glecaprevir should not be used in patients with severe liver impairment (Child-Pugh C). If you have other liver conditions, discuss with your doctor before starting treatment.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double up doses.

Are there any foods or medicines I should avoid?

Avoid taking glecaprevir with certain medications (like rifampin or atazanavir) and avoid alcohol. Always check with your doctor or pharmacist before starting new medicines.

What are the most common side effects?

The most common side effects are headache, fatigue, nausea, and diarrhea. Most are mild and temporary.

Is glecaprevir safe during pregnancy or breastfeeding?

There is limited data on the use of glecaprevir during pregnancy or breastfeeding. Discuss risks and benefits with your healthcare provider.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.