Sofosbuvir — Uses, Dosage, Side Effects & Safety

Drug class: Infectious & Communicable Diseases

Overview

Sofosbuvir is an antiviral medication used to treat chronic hepatitis C virus (HCV) infection in adults and children aged 3 years and older. It is usually prescribed in combination with other antiviral medicines, such as ledipasvir, velpatasvir, or ribavirin, depending on the specific type (genotype) of hepatitis C. Sofosbuvir works by blocking a key enzyme (NS5B RNA-dependent RNA polymerase) that the hepatitis C virus needs to multiply. By stopping the virus from replicating, Sofosbuvir helps clear the infection from the body. Key points for patients: Sofosbuvir is not used alone and must be taken with other antiviral drugs. It is important to take the medication exactly as prescribed and to complete the full course, even if you feel better. Missing doses can reduce the effectiveness of treatment and increase the risk of the virus becoming resistant.

Therapeutic uses

  • Chronic hepatitis C virus (HCV) infection
  • Genotype 1 chronic HCV infection
  • Genotype 2 chronic HCV infection
  • Genotype 3 chronic HCV infection
  • Genotype 4 chronic HCV infection

For related Sofosbuvir guidance, compare Lopinavir, Valganciclovir and Sofosbuvir/Ledipasvir.

Common side effects

  • Headache
  • Nausea
  • Fatigue
  • Diarrhea
  • Insomnia
  • Anemia
  • Bradycardia (when co-administered with amiodarone)

Frequently Asked Questions about Sofosbuvir

What is Sofosbuvir used for?

Sofosbuvir is used to treat chronic hepatitis C infection in adults and children, usually in combination with other antiviral medications.

Can Sofosbuvir cure hepatitis C?

Yes, Sofosbuvir-based regimens can cure hepatitis C in most patients when taken as prescribed for the full course.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double up doses.

Are there any foods or drinks I should avoid?

There are no specific food restrictions, but avoid grapefruit and grapefruit juice as they may interact with some hepatitis C medications.

Can I take Sofosbuvir if I am pregnant or breastfeeding?

The safety of Sofosbuvir in pregnancy and breastfeeding is not fully established. Discuss with your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Is Sofosbuvir safe for children?

Sofosbuvir is approved for use in children aged 3 years and older, with dosing based on body weight.

Can Sofosbuvir be used alone?

No, Sofosbuvir should always be used in combination with other antiviral medications for effective treatment.

Related Sofosbuvir information

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.