Raltitrexed — Uses, Dosage, Side Effects & Safety

Drug class: Antimetabolite (Antineoplastic Agent)

Overview

Raltitrexed is a chemotherapy medication used to treat certain types of cancer, most commonly advanced colorectal cancer. It is typically prescribed when other treatments, such as 5-fluorouracil (5-FU), are not suitable or have caused significant side effects. Raltitrexed works by blocking an enzyme called thymidylate synthase, which is essential for DNA synthesis in rapidly dividing cancer cells. By interfering with DNA production, it helps to slow or stop the growth of cancer. Patients should know that Raltitrexed is given as an intravenous infusion under medical supervision. Regular blood tests are required to monitor for side effects, and it is important to report any unusual symptoms to your healthcare provider promptly.

Therapeutic uses

  • Metastatic colorectal cancer
  • Malignant mesothelioma
  • Non-small cell lung cancer
  • Ovarian cancer

Common side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Myelosuppression
  • Stomatitis
  • Elevated liver enzymes
  • Skin rash

Frequently Asked Questions about Raltitrexed

What is Raltitrexed used for?

Raltitrexed is primarily used to treat advanced colorectal cancer, especially in patients who cannot tolerate 5-fluorouracil-based regimens.

How is Raltitrexed given?

It is administered as an intravenous infusion by a healthcare professional, usually every 3 weeks.

What should I do if I experience severe diarrhea or vomiting?

Contact your healthcare provider immediately, as these can be signs of serious toxicity that may require medical intervention.

Can I take Raltitrexed if I have kidney problems?

Raltitrexed is not recommended for patients with severe kidney impairment. Dose adjustments may be needed for mild to moderate impairment.

Are there any foods or medicines I should avoid?

Avoid live vaccines and folinic acid (leucovorin) unless prescribed. Inform your doctor about all medicines and supplements you are taking.

Is Raltitrexed safe during pregnancy or breastfeeding?

No, Raltitrexed should not be used during pregnancy or breastfeeding due to potential harm to the baby.

What monitoring is required during treatment?

Regular blood tests to monitor blood cell counts, liver and kidney function, and assessment for side effects are required.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.