Naldemedine — Uses, Dosage, Side Effects & Safety

Drug class: Peripherally Acting Mu-Opioid Receptor Antagonist (PAMORA)

Overview

Naldemedine is a prescription medication used to treat opioid-induced constipation (OIC) in adults who are taking opioid pain medicines for chronic non-cancer pain. Opioids can cause constipation by slowing down the movement of the gut, and Naldemedine works by blocking the effects of opioids on the bowel without affecting pain relief elsewhere in the body. Naldemedine is taken by mouth, usually once daily, and helps restore normal bowel movements. It is not a laxative, but specifically targets the cause of constipation related to opioid use. Patients should continue their opioid pain medication as prescribed and use Naldemedine only for opioid-induced constipation. Key points: Naldemedine should not be used for constipation unrelated to opioid use. It is important to inform your healthcare provider about all medications and medical conditions before starting Naldemedine.

Therapeutic uses

  • Opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain
  • Opioid-induced constipation (OIC) in adult patients with cancer

For related Naldemedine guidance, compare Naloxegol.

Common side effects

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Vomiting
  • Gastrointestinal perforation
  • Opioid withdrawal symptoms

Frequently Asked Questions about Naldemedine

What is Naldemedine used for?

Naldemedine is used to treat opioid-induced constipation (OIC) in adults who are taking opioid pain medications for chronic non-cancer pain.

How does Naldemedine work?

Naldemedine blocks opioid receptors in the gut, reducing constipation caused by opioid pain medications without affecting pain relief.

Can I take Naldemedine with other laxatives?

You should only use other laxatives if directed by your healthcare provider, as combining them may increase the risk of side effects.

What should I do if I experience severe diarrhea or abdominal pain?

Stop taking Naldemedine and contact your healthcare provider immediately, as these may be signs of a serious side effect.

Is Naldemedine safe during pregnancy or breastfeeding?

The safety of Naldemedine during pregnancy or breastfeeding is not established. Discuss with your doctor before use.

What happens if I stop taking my opioid pain medication?

If you stop taking opioid pain medication, you should also stop Naldemedine, as it is only effective for opioid-induced constipation.

Can children use Naldemedine?

Naldemedine is not recommended for use in children or adolescents under 18 years of age.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.