Janumet (Sitagliptin + Metformin (sitagliptin and metformin hydrochloride) — Uses, Dosage, Side Effects & Safety

Drug class: Oral antihyperglycemic agent (DPP-4 inhibitor + biguanide)

Overview

Janumet is a prescription medicine used to help control blood sugar levels in adults with type 2 diabetes mellitus. It combines two active ingredients: sitagliptin, a DPP-4 inhibitor, and metformin, a biguanide. Together, these medicines help your body manage blood sugar more effectively, especially when diet and exercise alone are not enough. Sitagliptin works by increasing the levels of natural substances called incretins, which help control blood sugar by increasing insulin release and decreasing the amount of sugar made by your liver. Metformin works mainly by reducing the amount of sugar your liver releases and improving your body's response to insulin. Janumet is not for use in people with type 1 diabetes or for the treatment of diabetic ketoacidosis. It is important to take this medication exactly as prescribed and to continue with your recommended diet and exercise plan.

Therapeutic uses

  • Type 2 diabetes mellitus (as an adjunct to diet and exercise)
  • Improve glycemic control in adults with type 2 diabetes mellitus

For related Janumet (Sitagliptin + Metformin guidance, compare Metformin in Canada, Metformin in France and Metformin in United States.

Common side effects

  • Nausea
  • Diarrhea
  • Abdominal pain
  • Upper respiratory tract infection
  • Hypoglycemia (when used with sulfonylurea or insulin)
  • Pancreatitis
  • Lactic acidosis

Frequently Asked Questions about Janumet (Sitagliptin + Metformin

What is Janumet used for?

Janumet is used to help control blood sugar levels in adults with type 2 diabetes mellitus, especially when diet and exercise alone are not enough.

How does Janumet work?

Janumet combines sitagliptin, which increases insulin release and decreases sugar production, with metformin, which reduces sugar made by the liver and improves insulin sensitivity.

What are the most common side effects?

Common side effects include diarrhea, nausea, vomiting, headache, and mild respiratory infections.

Can Janumet cause low blood sugar?

Janumet alone has a low risk of causing hypoglycemia, but the risk increases if combined with other diabetes medications like sulfonylureas or insulin.

Is Janumet safe during pregnancy or breastfeeding?

The safety of Janumet during pregnancy or breastfeeding is not well established. Consult your doctor before use if you are pregnant or breastfeeding.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up doses.

Can I drink alcohol while taking Janumet?

It is best to avoid excessive alcohol while taking Janumet, as it increases the risk of lactic acidosis.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.