Human Menopausal Gonadotropin
Pronunciation: (hyoo-muhn men-uh-PAW-zuhl goh-NAD-oh-troh-pin).
- Generic name
- Human menopausal gonadotropin
- Brand names
- Menogon, Menopur, Pergonal, Humog, Repronex, Humegon
- Drug class
- Endocrine & Hormonal
Availability and supply rules vary by country
Trade names by country: India
Australia: · Full directory
What Human menopausal gonadotropin is and how it works
Uses, formulations, monitoring, and supply rules can differ by patient, product, and country. Follow the exact local product information and professional advice.
Mechanism of action: how Human menopausal gonadotropin works
Human menopausal gonadotropin (hMG) is a purified preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) derived from the urine of postmenopausal women. FSH stimulates the growth and maturation of ovarian follicles, while LH triggers ovulation and supports luteal function. In men, hMG stimulates spermatogenesis by acting on the testes. (2)
What Human menopausal gonadotropin is used for
Infertility in women due to anovulation
Infertility in women due to anovulation (2)
Controlled ovarian hyperstimulation for assisted reproductive technologies (ART)
Controlled ovarian hyperstimulation for assisted reproductive technologies (ART) (2)
Hypogonadotropic hypogonadism in men to stimulate spermatogenesis
Hypogonadotropic hypogonadism in men to stimulate spermatogenesis (2)
Cryptorchidism (undescended testicles) in some cases
Cryptorchidism (undescended testicles) in some cases (2)
Before taking Human menopausal gonadotropin
Do not take / not appropriate for
- : pregnancy, primary ovarian failure, uncontrolled thyroid or adrenal dysfunction, hormone-dependent tumors, ovarian cysts unrelated to polycystic ovary syndrome, unexplained vaginal bleeding, and known hypersensitivity to hMG. (Contraindication) (2)
Tell your clinician about
(2)How to take Human menopausal gonadotropin
- General Instructions: hMG should be administered exactly as prescribed by your fertility specialist. It is usually given as a subcutaneous or intramuscular injection, often once daily during specific days of your fertility cycle.. Adult Dosing: Typical starting dose for ovulation induction is 75-150 IU daily, adjusted based on ovarian response (a commonly used generic hMG starting-dose convention). One branded product's approved label (Menopur) starts higher, at 225 IU daily, with adjustments of up to 150 IU per step, a maximum daily dose of 450 IU, and a maximum treatment duration of 20 days per cycle — the exact regimen depends on the specific product and must follow the prescriber's instructions. For assisted reproductive technology (ART), dosing may vary and is individualized.. Pediatric Dosing: Not routinely used in children. Use in pediatric patients is rare and should be determined by a specialist.. Administration: Administer as an injection under the skin (subcutaneous) or into the muscle (intramuscular), as instructed by your healthcare provider. Rotate injection sites to minimize irritation.. If Pregnancy Occurs Or OHSS Is Suspected: Contact your fertility specialist right away; hMG is stopped once pregnancy is confirmed or if there is evidence of ovarian hyperstimulation syndrome (OHSS), and the clinician managing your treatment will direct exactly when and how.. Storage: Store refrigerated or at room temperature, 3-25°C (37-77°F), protected from light. Do not freeze. Use reconstituted solution immediately unless the product labeling states otherwise.
- This page does not provide a dose calculator. Dosing must follow the prescriber, pharmacist, or product label.
Procedures and treatment changes
Tell the treating team before surgery, procedures, or any medicine change. Do not alter treatment without the responsible clinician. (2)
Missed dose
If you miss a dose, contact your healthcare provider immediately for instructions. Do not take an extra dose unless specifically advised to.
Overdose
Symptoms of overdose may include severe abdominal pain, bloating, nausea, vomiting, and signs of ovarian hyperstimulation syndrome (OHSS). Seek emergency medical attention if overdose is suspected. (2)
Side effects
Side effects and their urgency vary; report severe, persistent, or concerning symptoms to a healthcare professional.
Ovarian hyperstimulation syndrome (OHSS)
Incidence: Reported in the clinician-authored database; frequency not established
Abdominal pain or discomfort
Incidence: Reported in the clinician-authored database; frequency not established
Nausea
Incidence: Reported in the clinician-authored database; frequency not established
Vomiting
Incidence: Reported in the clinician-authored database; frequency not established
Headache
Incidence: Reported in the clinician-authored database; frequency not established
Breast tenderness
Incidence: Reported in the clinician-authored database; frequency not established
Injection site reactions
Incidence: Reported in the clinician-authored database; frequency not established
Multiple pregnancies
Incidence: Reported in the clinician-authored database; frequency not established
Serious warnings
Risk of ovarian hyperstimulation syndrome (OHSS), which can be life-threatening — reported in about 6 — serious
Symptoms: Risk of ovarian hyperstimulation syndrome (OHSS), which can be life-threatening — reported in about 6.2% of treated women in clinical trials, and can progress rapidly with a dramatic increase in vascular permeability and fluid accumulation. Increased risk of multiple pregnancies (twins, triplets, etc.) — occurred in about 35.3% of pregnancies in clinical trials. Potential for blood clots and thromboembolic events, both linked to and separate from OHSS, with higher risk in people with obesity or a thrombophilia (clotting disorder). May cause ovarian torsion in rare cases. Serious pulmonary conditions have also been reported, rarely fatal. Requires close monitoring with blood tests and ultrasounds.
Action: Follow the urgency stated and seek prompt or emergency care when indicated. (2)
Contraindications recorded in the clinician database — serious
Symptoms: Contraindications recorded in the clinician database: pregnancy, primary ovarian failure, uncontrolled thyroid or adrenal dysfunction, hormone-dependent tumors, ovarian cysts unrelated to polycystic ovary syndrome, unexplained vaginal bleeding, and known hypersensitivity to hMG. Precautions: use with caution in patients with risk factors for thromboembolic events, asthma, or those with enlarged ovaries. Independently confirmed additional contraindication: pituitary or hypothalamic tumors.
Action: Follow the urgency stated and seek prompt or emergency care when indicated. (2)
Interactions
| Medicine or test | Effect | Action |
|---|---|---|
| Recorded interactions | hMG is often used together with other fertility drugs, such as clomiphene citrate or GnRH agonists/antagonists, as part of a monitored fertility protocol — this is standard clinical practice rather than a documented pharmacologic drug interaction. No formal drug-drug interaction studies of hMG have been conducted in humans, so an interaction cannot be ruled out. Always inform your healthcare provider of all medicines and supplements you are taking. | (2) |
Pregnancy, breastfeeding, kidney/liver function, age
Pregnancy
hMG is contraindicated once pregnancy is confirmed (older FDA labeling places it in the most restrictive pregnancy category, historically "Category X" — do not use in pregnant women). It is used specifically to help achieve pregnancy and is then stopped; the fertility specialist managing treatment will direct the exact timing. (2)
Breastfeeding
It is not known whether hMG passes into human breast milk. The decision to continue or pause breastfeeding during treatment should be made with the prescribing fertility specialist, weighing the medication's importance against any potential infant exposure. (2)
Children
Frequency: Not applicable. Weight Based: Not recommended for pediatric use. Max Daily Dose: Not applicable. Max Single Dose: Not applicable. Age Restrictions: Safety not established in children (2)
Renal_impairment
Renal- or hepatic-impairment dosing has not been established in the clinician record or in the independent literature reviewed; anyone with significant kidney or liver disease should have their fertility specialist individualize monitoring and dosing. (2)
Hepatic_impairment
Renal- or hepatic-impairment dosing has not been established in the clinician record or in the independent literature reviewed; anyone with significant kidney or liver disease should have their fertility specialist individualize monitoring and dosing. (2)
Monitoring
(2)Storage
Store refrigerated or at room temperature, 3-25°C (37-77°F), protected from light. Do not freeze. Use the reconstituted solution immediately unless the specific product's labeling states otherwise. Keep out of reach of children.
Professional information
Clinician-facing context only. This section does not replace current product labeling.
General — generic hMG starting-dose convention
Indication: Infertility in women due to anovulation
Dose summary: The standard initial dose is 75 to 150 IU administered intramuscularly or subcutaneously daily, adjusted by ovarian response.
Renal context: No validated renal-dose-adjustment protocol was found in the clinician record or the independent literature reviewed. (2)
General — Menopur brand-specific FDA label
Indication: Controlled ovarian hyperstimulation / ovulation induction
Dose summary: Initial 225 IU subcutaneously daily; after 5 days, adjust by up to 150 IU per step based on ovarian response. Maximum daily dose 450 IU. Maximum treatment duration 20 days per cycle.
Renal context: No validated renal-dose-adjustment protocol found. (2)
Frequently asked questions
How does human menopausal gonadotropin (hMG) help with fertility?
hMG contains FSH and LH, which stimulate the ovaries to develop and release eggs, increasing the chance of pregnancy in women who have trouble ovulating.
What are the signs of ovarian hyperstimulation syndrome (OHSS)?
Signs include severe abdominal pain, rapid weight gain, bloating, nausea, vomiting, and decreased urination. Contact your doctor immediately if you notice these symptoms.
Can hMG be used in men?
Yes, hMG can be used in men with certain types of infertility to stimulate sperm production, usually in combination with other hormones.
How is hMG administered?
hMG is given as an injection under the skin or into a muscle, usually by a healthcare provider or after proper training for self-administration.
What should I do if I miss a dose?
Contact your healthcare provider for instructions. Do not take an extra dose unless specifically told to do so.
Are there any dietary restrictions while using hMG?
There are no specific dietary restrictions, but maintaining a healthy, balanced diet is recommended during fertility treatment.
Is it safe to use hMG during pregnancy or breastfeeding?
hMG is contraindicated once pregnancy is confirmed, and its use during breastfeeding has not been studied. Tell your doctor right away if you become pregnant while using this medication so they can advise on next steps.
What happens if I take too much Human menopausal gonadotropin (hMG)?
Taking too much hMG can lead to severe ovarian hyperstimulation syndrome (OHSS), characterized by symptoms like severe abdominal pain, bloating, nausea, vomiting, and reduced urination. In such cases, it is crucial to seek immediate emergency medical attention. Overdose can also increase the risk of blood clots and kidney problems.
Can I drink alcohol while taking Human menopausal gonadotropin (hMG)?
While there are no direct contraindications between alcohol and hMG, it is generally advisable to limit or avoid alcohol consumption during fertility treatments. Alcohol can potentially interfere with hormone levels and overall reproductive health, which may impact the effectiveness of hMG therapy. Consult your healthcare provider for personalized advice.
Is Human menopausal gonadotropin (hMG) safe during pregnancy?
Human menopausal gonadotropin (hMG) is not intended for use during pregnancy. It falls under a pregnancy category that advises against its use once pregnancy is confirmed. If you become pregnant while undergoing hMG treatment, contact your doctor right away — your fertility specialist will confirm the pregnancy and direct exactly when and how to stop hMG.
What is the mechanism of action of Human menopausal gonadotropin?
Human menopausal gonadotropin (hMG) is a purified preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) derived from the urine of postmenopausal women. FSH stimulates the growth and maturation of ovarian follicles, while LH triggers ovulation and supports luteal function. In men, hMG stimulates spermatogenesis by acting on the testes. (2)
What is the generic name of Human Menopausal Gonadotropin?
The generic name is Human menopausal gonadotropin. It is sold under brand names including Menogon, Menopur, Pergonal, Humog, Repronex, Humegon.
What class of drug is Human menopausal gonadotropin?
Human Menopausal Gonadotropin is classed as: Endocrine & Hormonal.
References
- Human menopausal gonadotropin (hMG) - MedGuideGlobal Clinician MonographMedGuideGlobal · Global · accessed 2026-08-06 · source 1
- MENOPUR (menotropins for injection) prescribing informationU.S. Food and Drug Administration · United States · accessed 2026-08-06 · source 2
Brand names by country
Single-ingredient Human menopausal gonadotropin names are shown separately by country. Product availability, strengths, and supply rules can change; combination products are not included here.
Priority countries
India
- Lupi HMG75 IU, 150 IU · Lupin
- GMH HP150 IU · Sun Pharma
- Humog150 IU · Bharat Serums & Vaccines Ltd