Flurandrenolide
Pronunciation: (flure-an-DREN-oh-lide).
- Generic name
- Flurandrenolide
- Brand names
- Cordran Tape, Flurand, Flurandren, Cordran
- Drug class
- Topical Corticosteroid
Availability and supply rules vary by country
Trade names by country: United States
Australia: · Full directory
What Flurandrenolide is and how it works
Uses, formulations, monitoring, and supply rules can differ by patient, product, and country. Follow the exact local product information and professional advice.
Mechanism of action: how Flurandrenolide works
Flurandrenolide is a synthetic fluorinated corticosteroid that exerts anti-inflammatory, antipruritic, and vasoconstrictive effects when applied topically. It binds to cytoplasmic glucocorticoid receptors, modulating gene expression and suppressing the release of inflammatory mediators such as prostaglandins and leukotrienes. (1)
What Flurandrenolide is used for
Psoriasis
Psoriasis (2)
Eczema
Eczema (2)
Dermatitis
Dermatitis (2)
Allergic skin conditions
Allergic skin conditions (2)
Before taking Flurandrenolide
Do not take / not appropriate for
- Contraindicated in patients with hypersensitivity to flurandrenolide or any component of the formulation, and in those with untreated skin infections (bacterial, viral, or fungal). (Contraindication) (2)
Tell your clinician about
(2)How to take Flurandrenolide
- General Instructions: Apply a thin layer to the affected skin area 1 to 3 times daily, as prescribed. Wash hands before and after use.. Adult Dosing: Apply a thin film to the affected area 1-3 times daily. For tape, apply to clean, dry skin and replace as directed (usually every 12-24 hours).. Pediatric Dosing: Use the lowest effective dose for the shortest duration. Children are more susceptible to side effects; consult a pediatrician for dosing.. Administration: For external use only. Do not apply to the face, groin, or underarms unless directed. Avoid contact with eyes and mucous membranes.. When To Stop: Discontinue when symptoms resolve, following your prescriber's instructions. If irritation or a possible allergic reaction occurs, seek medical advice promptly; let the clinician you see advise on whether to continue or stop. If there is no improvement within 2 weeks, your diagnosis should be reassessed by your clinician. Do not use longer than prescribed.. Storage: Store at room temperature, away from heat and moisture. Keep out of reach of children.
- This page does not provide a dose calculator. Dosing must follow the prescriber, pharmacist, or product label.
Procedures and treatment changes
Tell the treating team before surgery, procedures, or any medicine change. Do not alter treatment without the responsible clinician. (2)
Missed dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Overdose
Overuse or accidental ingestion can cause systemic corticosteroid effects, such as adrenal suppression. If swallowed or if large amounts are used over a long period, seek emergency medical attention or contact a poison control center immediately. (2)
Side effects
Side effects and their urgency vary; report severe, persistent, or concerning symptoms to a healthcare professional.
Skin atrophy
Incidence: Reported in the clinician-authored database; frequency not established
Burning/itching/irritation at application site
Incidence: Reported in the clinician-authored database; frequency not established
Stretch marks (striae)
Incidence: Reported in the clinician-authored database; frequency not established
Acne-like eruptions
Incidence: Reported in the clinician-authored database; frequency not established
Folliculitis
Incidence: Reported in the clinician-authored database; frequency not established
Hypopigmentation
Incidence: Reported in the clinician-authored database; frequency not established
Cushing's syndrome (with prolonged/extensive use)
Incidence: Reported in the clinician-authored database; frequency not established
Signs of skin infection at the treated area, worsening irritation, or a possible allergic reaction (rash, hives, swelling)
(1)In children: signs of intracranial hypertension (headache, bulging soft spot in infants, vision changes) or signs of slowed growth/weight gain
(2)Signs of systemic corticosteroid effect: unusual weight gain, rounded ('moon') face, or muscle weakness
(1)Serious warnings
Prolonged use may cause skin thinning or stretch marks — serious
Symptoms: Prolonged use may cause skin thinning or stretch marks. Systemic absorption can occur, especially in children or with large area application. Do not use on infected skin unless infection is being treated. Avoid contact with eyes and mucous membranes. Notify your doctor if symptoms worsen or do not improve.
Action: Follow the urgency stated and seek prompt or emergency care when indicated. (2)
Contraindications recorded in the clinician database — serious
Symptoms: Contraindications recorded in the clinician database: Contraindicated in patients with hypersensitivity to flurandrenolide or any component of the formulation, and in those with untreated skin infections (bacterial, viral, or fungal). Use with caution in children, patients with skin atrophy, or those requiring long-term therapy. Note: the FDA label's formal contraindication is hypersensitivity only; the untreated-infection caution appears in its warnings (discontinue and treat the infection before resuming) rather than as a formal contraindication — a labeling-format difference, not a safety disagreement.
Action: Follow the urgency stated and seek prompt or emergency care when indicated. (2)
Topical absorption of flurandrenolide can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, hyperglycemia, and glucosuria — serious
Symptoms: Topical absorption of flurandrenolide can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, hyperglycemia, and glucosuria; risk increases with more potent use, larger treated areas, prolonged use, and occlusive dressings. A clinician may check urinary free cortisol or an ACTH stimulation test if high-dose or large-area use is needed. Children are more susceptible than adults because of a larger skin-surface-to-body-weight ratio; reported pediatric effects include slowed growth, delayed weight gain, and intracranial hypertension (signs include headache, bulging soft spot in infants, or vision changes) — use the minimum effective amount and duration in children, under close clinician supervision. If there is no improvement within 2 weeks, the diagnosis should be reassessed by the treating clinician.
Action: Follow the urgency stated and seek prompt or emergency care when indicated. (2)
Interactions
| Medicine or test | Effect | Action |
|---|---|---|
| Recorded interactions | Flurandrenolide is unlikely to interact with oral medications due to minimal systemic absorption when used as directed. However, using other topical corticosteroids or products that irritate the skin may increase the risk of side effects. Inform your healthcare provider about all medications and skin products you use. | (1) |
Pregnancy, breastfeeding, kidney/liver function, age
Pregnancy
The FDA label classifies flurandrenolide as Pregnancy Category C: potent topical corticosteroids have shown teratogenic effects in animal studies. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your prescriber. (2)
Breastfeeding
The FDA label advises caution in nursing mothers, since the risk of systemic absorption reaching breast milk is unknown. Discuss breastfeeding with your healthcare provider before use, especially over large areas or for prolonged periods. (2)
Children
Frequency: Not established.. Weight Based: Not recommended for pediatric use.. Max Daily Dose: Not established.. Max Single Dose: Not established.. Age Restrictions: Safety not established in children. The FDA label notes children absorb proportionally more corticosteroid than adults and are at higher risk of HPA-axis suppression, growth retardation, and intracranial hypertension. (2)
Renal_impairment
No specific renal- or hepatic-impairment dosing guidance is established in either source reviewed; this remains a genuine gap given the drug's low systemic absorption when used as directed. (2)
Hepatic_impairment
No specific renal- or hepatic-impairment dosing guidance is established in either source reviewed; this remains a genuine gap given the drug's low systemic absorption when used as directed. (2)
Monitoring
(2)Storage
Store at controlled room temperature, 20-25°C (68-77°F), tightly closed and protected from light and moisture. Keep out of reach of children.
Professional information
Clinician-facing context only. This section does not replace current product labeling.
General
Indication: Corticosteroid-responsive dermatoses (FDA label term encompassing psoriasis, eczema, dermatitis, and allergic skin conditions)
Dose summary: Apply a small quantity/thin film 1-3 times daily (2-3 times daily for moist lesions per FDA label); discontinue when control is achieved; reassess diagnosis if no improvement within 2 weeks. Do not use occlusive dressings unless directed by a physician.
Renal context: No specific renal- or hepatic-impairment dosing guidance is established in either source reviewed. (1) (2)
Frequently asked questions
What conditions does flurandrenolide treat?
Flurandrenolide is used to treat inflammatory and itchy skin conditions such as eczema, dermatitis, allergic reactions, and certain rashes.
How quickly does flurandrenolide work?
Most people notice improvement in itching and redness within a few days of starting treatment. Full effects may take up to 1-2 weeks.
Can I use flurandrenolide on my face?
Do not use flurandrenolide on the face unless specifically directed by your healthcare provider, as the skin is more sensitive and side effects are more likely.
Is flurandrenolide safe for children?
It can be used in children, but only under close medical supervision and for the shortest time possible, as children are more prone to side effects.
What should I do if my skin gets worse while using flurandrenolide?
Contact your healthcare provider promptly if your skin becomes more irritated, develops signs of infection, or if your symptoms do not improve; they will advise on whether to continue or stop the medication.
Can I use other skin products with flurandrenolide?
Consult your doctor before using other topical products on the same area, as some may interact or increase irritation.
Is it safe to use flurandrenolide during pregnancy or breastfeeding?
Use only if clearly needed and directed by your doctor. Avoid applying to large areas or for prolonged periods during pregnancy or breastfeeding.
What happens if I take too much Flurandrenolide?
Applying excessive amounts of Flurandrenolide, especially over large areas or for prolonged periods, can lead to systemic absorption and potential side effects such as Cushing's syndrome, hyperglycemia, or adrenal suppression. If you suspect an overdose or experience unusual symptoms like weight gain, moon face, or muscle weakness, seek emergency medical attention immediately. Always follow your doctor's prescribed dosage.
Can I drink alcohol while taking Flurandrenolide?
As a topical corticosteroid, Flurandrenolide is not known to have direct interactions with alcohol. However, alcohol consumption can sometimes exacerbate certain skin conditions or impair the body's healing process. While moderate alcohol intake is generally not contraindicated, it's always best to discuss your alcohol consumption habits with your healthcare provider to ensure it doesn't interfere with your treatment or underlying condition.
Is Flurandrenolide safe during pregnancy?
Flurandrenolide is FDA Pregnancy Category C: potent topical corticosteroids have shown teratogenic effects in animal studies, so it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. While topical absorption is generally low, systemic effects are possible, especially with extensive use. It is crucial to consult your doctor before using Flurandrenolide if you are pregnant, planning to become pregnant, or breastfeeding.
What is the mechanism of action of Flurandrenolide?
Flurandrenolide is a synthetic fluorinated corticosteroid that exerts anti-inflammatory, antipruritic, and vasoconstrictive effects when applied topically. It binds to cytoplasmic glucocorticoid receptors, modulating gene expression and suppressing the release of inflammatory mediators such as prostaglandins and leukotrienes. (1)
What is the generic name of Flurandrenolide?
The generic name is Flurandrenolide. It is sold under brand names including Cordran Tape, Flurand, Flurandren, Cordran.
What class of drug is Flurandrenolide?
Flurandrenolide is classed as: Topical Corticosteroid.
References
- Flurandrenolide clinician-authored medicine recordMedGuideGlobal · Not applicable (internal database) · accessed 2026-08-06 · source 1
- CORDRAN (flurandrenolide) cream prescribing informationU.S. Food and Drug Administration · United States · accessed 2026-08-06 · source 2
- CORDRAN (FLURANDRENOLIDE) CREAM [INA PHARMACEUTICS, INC] — US prescribing information (DailyMed SPL)U.S. National Library of Medicine (DailyMed) · US · accessed 2026-08-14 · source 3
- Flurandrenolide Topical — patient drug information (MedlinePlus)U.S. National Library of Medicine (MedlinePlus) · US · accessed 2026-08-14 · source 4
- Flurandrenolide — FDA approval record (Drugs@FDA ANDA207133)U.S. Food and Drug Administration · US · accessed 2026-08-14 · source 5
- Flurandrenolide — RxNorm normalized drug concept (RXCUI 4500)U.S. National Library of Medicine (RxNorm) · US · accessed 2026-08-14 · source 6
Brand names by country
Single-ingredient Flurandrenolide names are shown separately by country. Product availability, strengths, and supply rules can change; combination products are not included here.
Priority countries
United States
- CORDRAN4 ug/cm2, .5 mg/g · almirall, llc