Fluocinolone Acetonide
Pronunciation: (floo-oh-SIN-oh-lone a-SEE-toe-nide).
- Generic name
- Fluocinolone acetonide
- Brand names
- Fluocinolone Acetonide Sandoz, Retisert, Fluocinolone Acetonide Cream, Flucort-H, Derma-Smoothe/FS, Flunilone
- Drug class
- Topical corticosteroid
Availability and supply rules vary by country
Trade names by country: United States · Canada
Australia: · Full directory
What Fluocinolone acetonide is and how it works
Uses, formulations, monitoring, and supply rules can differ by patient, product, and country. Follow the exact local product information and professional advice.
Mechanism of action: how Fluocinolone acetonide works
Fluocinolone acetonide is a synthetic fluorinated corticosteroid that exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by inhibiting the release of inflammatory mediators and suppressing leukocyte migration. It binds to glucocorticoid receptors, modulating gene expression and reducing cytokine production. (1)
What Fluocinolone acetonide is used for
Corticosteroid-responsive dermatoses (topical) — including eczema, dermatitis, and allergic skin conditions
The FDA-labeled indication for topical fluocinolone acetonide is the general category 'relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.' Eczema, dermatitis, and allergic skin conditions are common examples within this labeled category rather than separately named FDA indications. (2)
Psoriasis (within corticosteroid-responsive dermatoses)
Psoriasis plaques are commonly treated with topical corticosteroids as part of the general labeled category; potency and occlusion considerations for psoriasis should be guided by the prescriber. (2)
Chronic non-infectious uveitis affecting the posterior segment of the eye (intravitreal implant — a distinct product/route from the topical forms)
This is a different product and route of administration (surgically placed implant) from the topical cream/ointment/solution; implant-specific dosing and labeling were not reviewed in this research pass and should not be assumed to follow the topical product's warnings or dosing. (2)
Before taking Fluocinolone acetonide
Do not take / not appropriate for
- Contraindicated in patients with hypersensitivity to fluocinolone acetonide or any component, and in untreated skin infections (bacterial, viral, fungal). (Contraindication) (2)
Tell your clinician about
(2)How to take Fluocinolone acetonide
- General Instructions: Apply a thin layer to the affected area 1-2 times daily, as prescribed. For the eye implant, administration is performed by an ophthalmologist.. Adult Dosing: Topical: Apply a thin film to the affected area 1-2 times daily. Eye implant: Dose and frequency determined by ophthalmologist.. Pediatric Dosing: Use the lowest effective dose for the shortest duration. Not recommended for children under 2 years unless directed.. Administration: Wash hands before and after use. Do not cover with bandages unless instructed. Avoid contact with eyes, mouth, or mucous membranes.. When To Stop: If irritation, an allergic reaction, or infection develops, seek medical advice promptly; let the clinician you see advise on whether to continue or stop this medicine.. Storage: Store at room temperature 15-25°C (59-77°F), away from moisture and heat above 40°C (104°F); do not freeze. Keep out of reach of children.
- This page does not provide a dose calculator. Dosing must follow the prescriber, pharmacist, or product label.
Procedures and treatment changes
Tell the treating team before surgery, procedures, or any medicine change. Do not alter treatment without the responsible clinician. (2)
Missed dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not apply an extra dose to catch up.
Overdose
Excessive or prolonged use can cause systemic side effects, including adrenal suppression. In case of accidental ingestion or severe symptoms, seek emergency medical attention immediately. (2)
Side effects
Side effects and their urgency vary; report severe, persistent, or concerning symptoms to a healthcare professional.
Skin atrophy
Incidence: Reported in the clinician-authored database; frequency not established
Burning/stinging at application site
Incidence: Reported in the clinician-authored database; frequency not established
Itching
Incidence: Reported in the clinician-authored database; frequency not established
Folliculitis
Incidence: Reported in the clinician-authored database; frequency not established
Acneiform eruptions
Incidence: Reported in the clinician-authored database; frequency not established
Hypopigmentation
Incidence: Reported in the clinician-authored database; frequency not established
Allergic contact dermatitis
Incidence: Reported in the clinician-authored database; frequency not established
Cushing's syndrome (with prolonged use)
Incidence: Reported in the clinician-authored database; frequency not established
Serious warnings
Prolonged use may cause skin thinning and stretch marks — serious
Symptoms: Prolonged use may cause skin thinning and stretch marks. Systemic absorption can occur, especially in children or with large area use, and can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, hyperglycemia, and glucosuria; risk increases with higher potency, larger treated area, prolonged use, and occlusive dressings, and periodic HPA-axis monitoring is recommended with large doses. May worsen existing skin infections. Use caution in sensitive areas (face, groin, underarms). Children are more susceptible to HPA-axis suppression due to a larger skin-surface-to-body-weight ratio, and chronic therapy may interfere with growth and development.
Action: Follow the urgency stated and seek prompt or emergency care when indicated. (2)
Contraindications recorded in the clinician database — serious
Symptoms: Contraindications recorded in the clinician database: Contraindicated in patients with hypersensitivity to fluocinolone acetonide or any component, and in untreated skin infections (bacterial, viral, fungal). Use caution in children, pregnant or breastfeeding women, and those with skin atrophy or systemic corticosteroid exposure.
Action: Follow the urgency stated and seek prompt or emergency care when indicated. (2)
Interactions
| Medicine or test | Effect | Action |
|---|---|---|
| Recorded interactions | Fluocinolone acetonide may interact with other topical or systemic corticosteroids, increasing the risk of side effects. Avoid using with other skin products containing corticosteroids unless directed. No significant drug interactions are reported with the eye implant, but always inform your healthcare provider of all medications you are taking. | (1) |
Pregnancy, breastfeeding, kidney/liver function, age
Pregnancy
FDA Pregnancy Category C — animal studies have shown an adverse effect on the fetus, and adequate, well-controlled human studies are lacking. Use only if the potential benefit justifies the potential risk to the fetus, and avoid extensive use in pregnancy; discuss with your healthcare provider. (2)
Breastfeeding
It is not known whether topical corticosteroids appear in breast milk; caution is advised for nursing mothers. Discuss with your healthcare provider before use while breastfeeding. (2)
Children
Frequency: Not applicable.. Weight Based: Not recommended for pediatric use.. Max Daily Dose: Not applicable.. Max Single Dose: Not applicable.. Age Restrictions: Safety not established in children. Children are more susceptible to HPA-axis suppression than adults due to a larger skin-surface-to-body-weight ratio, and chronic therapy may interfere with growth and development — use the lowest effective amount for the shortest duration. (2)
Renal_impairment
No dedicated renal or hepatic impairment dosing data were found in either source reviewed for this research pass; this is a topical product with limited systemic absorption under normal use, but anyone with significant organ impairment should ask their healthcare provider before extended or large-area use. (2)
Hepatic_impairment
No dedicated renal or hepatic impairment dosing data were found in either source reviewed for this research pass; this is a topical product with limited systemic absorption under normal use, but anyone with significant organ impairment should ask their healthcare provider before extended or large-area use. (2)
Monitoring
(2)Storage
Store at room temperature 15-25°C (59-77°F), away from moisture and heat above 40°C (104°F); do not freeze. Keep out of reach of children.
Professional information
Clinician-facing context only. This section does not replace current product labeling.
General
Indication: Corticosteroid-responsive dermatoses (topical)
Dose summary: Apply a thin film to the affected area once or twice daily per the clinician record; this label states 2-4 times daily depending on severity — check the specific product/strength label, as frequency varies by formulation. Occlusive dressings may be used for resistant conditions.
Renal context: No dedicated renal-impairment dosing data were found in either source reviewed for this research pass; systemic absorption from topical use is normally limited but increases with large treated areas, prolonged use, or occlusion, so caution is still warranted. (1) (2)
Frequently asked questions
What conditions does fluocinolone acetonide treat?
It is used to treat inflammatory skin conditions such as eczema, dermatitis, and allergic rashes. The eye implant is used for chronic non-infectious uveitis affecting the posterior segment of the eye.
How long can I use fluocinolone acetonide cream?
Use for the shortest duration necessary, typically no longer than 2-4 weeks unless directed by your doctor. Prolonged use increases the risk of side effects.
Can children use fluocinolone acetonide?
Children may use it under strict medical supervision, as they are more susceptible to side effects. Use the lowest effective dose for the shortest period.
Is it safe during pregnancy or breastfeeding?
Use only if clearly needed and prescribed by your doctor. Discuss risks and benefits with your healthcare provider.
What should I do if I develop skin irritation?
If you experience severe irritation, redness, or signs of infection, seek medical advice promptly; let the clinician you see advise on whether to continue or stop using this medicine.
Can I use other topical medications with fluocinolone acetonide?
Consult your doctor before combining with other topical treatments, especially other corticosteroids, to avoid increased side effects.
What are the signs of overdose or systemic absorption?
Symptoms may include unusual tiredness, weight loss, persistent nausea/vomiting, or signs of adrenal suppression. Seek medical attention if these occur.
What happens if I take too much Fluocinolone acetonide?
Applying excessive amounts of Fluocinolone acetonide, especially over large areas or for prolonged periods, can lead to systemic absorption and potential side effects such as Cushing's syndrome, hyperglycemia, or adrenal suppression. If you suspect an overdose or experience unusual symptoms like weight gain, moon face, or muscle weakness, seek immediate medical attention or contact emergency services.
Can I drink alcohol while taking Fluocinolone acetonide?
As Fluocinolone acetonide is a topical medication, direct interactions with alcohol are generally not expected. However, alcohol consumption can sometimes exacerbate certain skin conditions or cause dehydration, which might indirectly affect skin health. It's always best to discuss your alcohol intake with your healthcare provider, especially if you have underlying health conditions or are on other medications.
Is Fluocinolone acetonide safe during pregnancy?
The safety of Fluocinolone acetonide during pregnancy has not been definitively established. It is categorized as a Pregnancy Category C drug, meaning animal studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in humans. Therefore, it should only be used if the potential benefit justifies the potential risk to the fetus. Always consult your doctor before using this medication if you are pregnant or planning to become pregnant.
What is the mechanism of action of Fluocinolone acetonide?
Fluocinolone acetonide is a synthetic fluorinated corticosteroid that exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by inhibiting the release of inflammatory mediators and suppressing leukocyte migration. It binds to glucocorticoid receptors, modulating gene expression and reducing cytokine production. (1)
What is the generic name of Fluocinolone Acetonide?
The generic name is Fluocinolone acetonide. It is sold under brand names including Fluocinolone Acetonide Sandoz, Retisert, Fluocinolone Acetonide Cream, Flucort-H, Derma-Smoothe/FS, Flunilone.
What class of drug is Fluocinolone acetonide?
Fluocinolone Acetonide is classed as: Topical corticosteroid.
References
- Fluocinolone Acetonide - Clinician Medicine RecordMedGuideGlobal · Global (Internal) · accessed 2026-08-06 · source 1
- SYNALAR (fluocinolone acetonide) Cream 0.025% — prescribing informationU.S. Food and Drug Administration · United States · accessed 2026-08-06 · source 2
- FLUOCINOLONE ACETONIDE OIL [BRYANT RANCH PREPACK] — US prescribing information (DailyMed SPL)U.S. National Library of Medicine (DailyMed) · US · accessed 2026-08-14 · source 3
- Fluocinolone Topical — patient drug information (MedlinePlus)U.S. National Library of Medicine (MedlinePlus) · US · accessed 2026-08-14 · source 4
- Fluocinolone Acetonide — FDA approval record (Drugs@FDA ANDA089124)U.S. Food and Drug Administration · US · accessed 2026-08-14 · source 5
- Fluocinolone acetonide — RxNorm normalized drug concept (RXCUI 4461)U.S. National Library of Medicine (RxNorm) · US · accessed 2026-08-14 · source 6
Brand names by country
Single-ingredient Fluocinolone acetonide names are shown separately by country. Product availability, strengths, and supply rules can change; combination products are not included here.
Priority countries
United States
- Fluocinolone Acetonide Oil.11 mg/mL · a-s medication solutions
- Derma-Smoothe/FS.11 mg/mL · royal pharmaceuticals, llc
- Synalar.25 mg/g · medimetriks pharmaceuticals, inc.
- Retisert.59 mg · bausch & lomb incorporated
- Iluvien.19 mg · ani pharmaceuticals, inc.
- DERMOTIC.11 mg/mL · royal pharmaceuticals
- Flac Otic Oil.11 mg/mL · patrin pharma, inc.
- YUTIQ.18 mg · ani pharmaceuticals, inc.
Canada
- SYNALAR
- FLUODERM CRM
- DERMA SMOOTHE/FS
- DERMOTIC OIL EAR
- RETISERT
- FLUODERM ONT