Imiquimod

Pronunciation: (ih-MIH-kwih-mod).

Generic name: Imiquimod
Brand names: Aldara, Zyclara, Vyloma, Imutrex, Imiquimod Sandoz, Imiquimod
Drug class: Immune Response Modifier (Topical Immunomodulator)

Availability and supply rules vary by country

Trade names by country: United States · Canada

What Imiquimod is and how it works

Uses, formulations, monitoring, and supply rules can differ by patient, product, and country. Follow the exact local product information and professional advice.

Mechanism of action: how Imiquimod works

Imiquimod is a toll-like receptor 7 (TLR7) agonist that stimulates innate and adaptive immune responses. It induces the production of cytokines such as interferon-alpha, tumor necrosis factor-alpha, and interleukins, enhancing the body's ability to clear abnormal cells and viral infections. (1)

What Imiquimod is used for

External genital and perianal warts

Actinic keratosis on the face or scalp

Superficial basal cell carcinoma

Before taking Imiquimod

Do not take / not appropriate for

The US prescribing information for ZYCLARA lists no contraindications — section 4 of the label reads "None." The limits on using this cream are set out as warnings and precautions rather than as absolute contraindications, so read those and follow the prescriber's instructions. (all countries)
Do not put ZYCLARA in the eyes, on the lips or in the nostrils, or inside the anus or vagina — it is for topical use on the skin only. If it does reach those areas, rinse with water straight away. (all countries)

Tell your clinician about

If you are allergic to imiquimod, to any ingredient of the cream, or to other medicines, foods, or substances — say what the reaction was.
If you are using any other imiquimod product on the same area, as this can make local skin reactions more likely and more severe.
If you have an inflammatory skin condition, including chronic graft-versus-host disease, which this cream can worsen.

How to take Imiquimod

General Instructions: Apply a thin layer to the affected area as prescribed, usually once daily before bedtime. Wash hands before and after application.. Adult Dosing: For actinic keratosis: Apply once daily to the affected area for 2 weeks, then take a 2-week break, and repeat if needed. For genital warts: Apply once daily until warts clear, up to 8 weeks. For superficial basal cell carcinoma: Apply once daily for 6 weeks.. Pediatric Dosing: Safety and efficacy in children under 12 years have not been established. Use only if prescribed by a pediatric specialist.. Administration: Apply to clean, dry skin. Do not cover with airtight dressings. Leave on skin for 8 hours, then wash off with mild soap and water.. When To Seek Review: Seek medical advice promptly if severe skin reactions, allergic symptoms, or signs of infection develop; let the clinician you see advise on whether to continue or ask the prescriber about stopping it. Consult your provider if no improvement after the full course.. Storage: Store at room temperature (20–25°C/68–77°F), away from moisture and heat. Keep out of reach of children.
This page does not provide a dose calculator. Dosing must follow the prescriber, pharmacist, or product label.

Procedures and treatment changes

Tell the treating team before surgery, procedures, or any medicine change. Do not alter treatment without the responsible clinician.

Missed dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, contact your prescriber or pharmacist for guidance on the missed dose and resume your regular schedule. Do not apply extra cream to make up for a missed dose.

Overdose

Accidental overdose is unlikely with topical use. If large amounts are applied or ingested, seek medical attention immediately. Symptoms may include severe skin irritation, headache, nausea, or systemic effects.

Side effects

Side effects and their urgency vary; report severe, persistent, or concerning symptoms to a healthcare professional.