Zileuton (zileuton) — Uses, Dosage, Side Effects & Safety

Drug class: Leukotriene synthesis inhibitor (5-lipoxygenase inhibitor)

Overview

Zileuton is a prescription medication used to help control and prevent symptoms of asthma in adults and children aged 12 years and older. It works by blocking the production of leukotrienes, substances in the body that cause inflammation, swelling, and tightening of the airways. By reducing leukotriene levels, zileuton helps decrease asthma attacks and improves breathing. Zileuton is not a rescue medication and should not be used to treat sudden asthma attacks. It is taken regularly to help keep asthma under control. Patients should continue using their other asthma medications unless told otherwise by their healthcare provider. Key points: Take zileuton exactly as prescribed, do not stop suddenly, and report any signs of liver problems (such as yellowing of the skin or eyes) to your doctor right away.

Therapeutic uses

  • Asthma prophylaxis
  • Chronic asthma management
  • Exercise-induced asthma prevention

Common side effects

  • Headache
  • Nausea
  • Abdominal pain
  • Insomnia
  • Elevated liver enzymes
  • Dizziness
  • Flu-like symptoms

Frequently Asked Questions about Zileuton

What is zileuton used for?

Zileuton is used to help control and prevent symptoms of asthma in adults and children aged 12 years and older. It is not used for treating sudden asthma attacks.

How does zileuton work?

Zileuton blocks the enzyme 5-lipoxygenase, which is involved in the production of leukotrienes. Leukotrienes cause inflammation and narrowing of the airways in asthma.

What are the most common side effects of zileuton?

Common side effects include headache, nausea, upset stomach, diarrhea, and abdominal pain. Liver enzyme elevations may also occur.

Can zileuton be used in children?

Zileuton is approved for use in children aged 12 years and older. Its safety and effectiveness in children under 12 years have not been established.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at once.

Are there any serious risks with zileuton?

Yes, zileuton can cause serious liver injury. Regular liver function tests are required, and any symptoms of liver problems should be reported immediately.

Can I stop taking zileuton if I feel better?

No, do not stop taking zileuton without consulting your doctor. Stopping suddenly may worsen your asthma control.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.