Yondelis (Trabectedin) (trabectedin) — Uses, Dosage, Side Effects & Safety

Drug class: Antineoplastic agent (Alkylating agent, Marine-derived cytotoxic)

Overview

Yondelis (trabectedin) is a chemotherapy medication used to treat certain types of soft tissue sarcoma and relapsed ovarian cancer. It is typically prescribed when other treatments have not been effective or when the cancer has returned. Trabectedin works by binding to the DNA in cancer cells, interfering with their ability to grow and divide. This action helps slow or stop the spread of cancer. Yondelis is administered as an intravenous infusion in a hospital or clinic setting under the supervision of a healthcare professional. Key points for patients: Yondelis can cause significant side effects, including effects on the liver, blood cells, and muscles. Regular blood tests and monitoring are required during treatment. Always inform your healthcare provider about any other medications or supplements you are taking.

Therapeutic uses

  • Advanced soft tissue sarcoma (STS)
  • Relapsed platinum-sensitive ovarian cancer

Common side effects

  • Myelosuppression (neutropenia, thrombocytopenia)
  • Nausea and vomiting
  • Fatigue
  • Elevated liver enzymes (ALT, AST)
  • Anemia
  • Peripheral neuropathy
  • Rhabdomyolysis
  • Cardiac dysfunction

Frequently Asked Questions about Yondelis (Trabectedin)

What types of cancer does Yondelis treat?

Yondelis is approved for the treatment of advanced soft tissue sarcoma and relapsed ovarian cancer, usually after other treatments have failed.

How is Yondelis administered?

It is given as a slow intravenous infusion over 24 hours, typically every 3 weeks, in a hospital or clinic setting.

What are the most serious side effects of Yondelis?

Serious side effects include liver toxicity, severe low blood counts, rhabdomyolysis (muscle breakdown), and severe infections.

Can I take Yondelis if I am pregnant or breastfeeding?

No. Yondelis can harm an unborn baby and is not recommended during pregnancy or breastfeeding. Use effective contraception during treatment.

Are there any foods or medicines I should avoid while on Yondelis?

Avoid grapefruit products and medicines that affect liver enzymes (CYP3A4 inducers/inhibitors) unless approved by your doctor.

How will my doctor monitor me during Yondelis treatment?

Your doctor will order regular blood tests to monitor your liver function, blood cell counts, and muscle enzymes. Monitoring helps detect side effects early.

What should I do if I experience severe side effects?

Contact your healthcare provider immediately or seek emergency care if you have symptoms such as severe muscle pain, jaundice, fever, or signs of infection.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.