Xyrem (Sodium oxybate) — Uses, Dosage, Side Effects & Safety

Drug class: Central Nervous System Depressant; GABA-B Agonist

Overview

Xyrem is a prescription medication used to treat cataplexy (sudden muscle weakness) and excessive daytime sleepiness in patients with narcolepsy, a chronic sleep disorder. It works by affecting certain chemicals in the brain that help regulate sleep and wakefulness. Xyrem contains sodium oxybate, which is a central nervous system depressant. It helps improve nighttime sleep, reduces episodes of cataplexy, and can help patients feel more alert during the day. Because of its strong sedative effects, Xyrem is only available through a restricted distribution program. Patients should be aware that Xyrem can cause drowsiness, confusion, and has a risk of misuse or abuse. It is important to take this medication exactly as prescribed and never share it with others.

Therapeutic uses

  • Narcolepsy with cataplexy
  • Excessive daytime sleepiness (EDS) in narcolepsy
  • Idiopathic hypersomnia

Common side effects

  • Nausea
  • Dizziness
  • Somnolence
  • Vomiting
  • Headache
  • Enuresis
  • Respiratory depression
  • Suicidal ideation

Frequently Asked Questions about Xyrem

What is Xyrem used for?

Xyrem is used to treat cataplexy and excessive daytime sleepiness in people with narcolepsy.

How does Xyrem work?

Xyrem works by acting on GABA-B receptors in the brain, helping to regulate sleep cycles and reduce symptoms of narcolepsy.

Is Xyrem addictive?

Yes, Xyrem has a high potential for abuse and dependence. It is only available through a restricted program.

Can I drink alcohol while taking Xyrem?

No. Alcohol increases the risk of serious side effects such as respiratory depression and should be avoided.

What should I do if I miss a dose?

Skip the missed dose and take your next dose at the regular time. Do not double up doses.

Can children take Xyrem?

Xyrem may be used in children 7 years and older for narcolepsy with cataplexy, but dosing must be carefully determined by a specialist.

What are the most serious risks of Xyrem?

Serious risks include respiratory depression, loss of consciousness, misuse or abuse, and severe allergic reactions.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.