Xpovio (selinexor) — Uses, Dosage, Side Effects & Safety

Drug class: Selective Inhibitor of Nuclear Export (SINE)

Overview

Xpovio (selinexor) is a prescription medicine used to treat certain types of blood cancers, including multiple myeloma and diffuse large B-cell lymphoma (DLBCL), especially in adults who have received several previous treatments that have not worked or have stopped working . It works by blocking a protein in cancer cells called exportin 1 (XPO1), which helps keep tumor-suppressing proteins inside the cell, leading to cancer cell death . Xpovio is usually taken in combination with other cancer medicines. It is important for patients to follow their healthcare provider’s instructions closely, as this medication can cause serious side effects and requires regular monitoring. Patients should be aware of the potential for nausea, fatigue, and low blood counts, and should report any unusual symptoms to their doctor promptly .

Therapeutic uses

  • Multiple myeloma
  • Diffuse large B-cell lymphoma
  • Myelofibrosis (in combination with ruxolitinib)

Common side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Thrombocytopenia
  • Anemia
  • Hyponatremia
  • Weight loss

Frequently Asked Questions about Xpovio

What is Xpovio used for?

Xpovio is used to treat adults with multiple myeloma and diffuse large B-cell lymphoma (DLBCL) who have received several prior therapies .

How does Xpovio work?

Xpovio blocks a protein called exportin 1 (XPO1), trapping tumor-suppressing proteins inside cancer cells and causing them to die .

What are the most common side effects of Xpovio?

The most common side effects include nausea, fatigue, low blood counts, decreased appetite, diarrhea, and weight loss .

Can I take Xpovio if I am pregnant or breastfeeding?

Xpovio is not recommended during pregnancy or breastfeeding due to potential harm to the baby. Discuss family planning with your doctor before starting treatment .

How should I store Xpovio tablets?

Store Xpovio at room temperature in the original container, away from moisture and light. Keep out of reach of children .

What should I do if I miss a dose?

Take the missed dose as soon as you remember on the same day. If it is the next day, skip the missed dose and continue your regular schedule. Do not double up doses .

Are there foods or medicines I should avoid while taking Xpovio?

Avoid grapefruit products and discuss all other medicines and supplements with your doctor to prevent interactions .

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.