Xiidra (lifitegrast ophthalmic) — Uses, Dosage, Side Effects & Safety

Drug class: Lymphocyte function-associated antigen-1 (LFA-1) antagonist; Ophthalmic anti-inflammatory agent

Overview

Xiidra is a prescription eye drop used to treat the signs and symptoms of dry eye disease (also known as keratoconjunctivitis sicca) in adults. Dry eye disease occurs when your eyes do not produce enough tears or when the tears evaporate too quickly, leading to discomfort, burning, and visual disturbances. Xiidra works by blocking a specific protein (LFA-1) involved in inflammation on the surface of the eye. By reducing inflammation, Xiidra helps relieve dryness, irritation, and discomfort associated with dry eye disease. Key points for patients: Xiidra is typically used twice daily in each eye. It may take several weeks to notice improvement. Some people may experience temporary eye irritation or an unusual taste after using the drops.

Therapeutic uses

  • Treatment of the signs and symptoms of dry eye disease

Common side effects

  • Eye irritation
  • Dysgeusia (unusual taste)
  • Reduced visual acuity
  • Conjunctival hyperemia
  • Punctate keratitis
  • Headache

Frequently Asked Questions about Xiidra

How long does it take for Xiidra to work?

Some patients may notice improvement in dry eye symptoms within a few weeks, but full benefit may take up to 12 weeks of consistent use.

Can I use Xiidra with contact lenses?

Remove contact lenses before using Xiidra. You may reinsert them 15 minutes after application.

What should I do if I experience an unusual taste after using Xiidra?

An unusual taste (dysgeusia) is a common side effect and is generally harmless. It usually resolves quickly.

Is Xiidra safe during pregnancy or breastfeeding?

There is limited data on the use of Xiidra in pregnancy or breastfeeding. Consult your healthcare provider for advice.

Can children use Xiidra?

The safety and effectiveness of Xiidra in children under 17 years have not been established.

What should I do if I accidentally use more than the recommended dose?

Overuse is unlikely to cause harm, but if you experience severe irritation or other symptoms, contact your healthcare provider.

Can I use other eye drops with Xiidra?

Yes, but wait at least 5 minutes between different eye medications to prevent dilution or interaction.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.