Xigduo XR (dapagliflozin and metformin hydrochloride extended-release) — Uses, Dosage, Side Effects & Safety

Drug class: Antidiabetic (SGLT2 inhibitor and biguanide combination)

Overview

Xigduo XR is a prescription medication used to help control blood sugar levels in adults with type 2 diabetes mellitus. It contains two active ingredients: dapagliflozin (an SGLT2 inhibitor) and metformin (a biguanide). Together, these medicines help your body remove excess sugar through urine and reduce the amount of sugar made by your liver. This medication is not for treating type 1 diabetes or diabetic ketoacidosis. Xigduo XR is usually used along with diet and exercise to improve blood sugar control. It may also help with weight loss and lower the risk of some diabetes-related complications. Key points for patients: Take Xigduo XR exactly as prescribed, usually once daily with food. Drink plenty of fluids to avoid dehydration. Tell your doctor about any kidney, liver, or heart problems before starting this medicine.

Therapeutic uses

  • Improve glycemic control in adults with type 2 diabetes mellitus
  • Reduce the risk of cardiovascular death and hospitalization for heart failure in adults with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors
  • Reduce the risk of hospitalization for heart failure in adults with heart failure with reduced ejection fraction (HFrEF)
  • Reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease (CKD) at risk of progression

For related Xigduo XR guidance, compare Metformin in Canada, Metformin in France and Metformin in United States.

Common side effects

  • Genital yeast infections
  • Urinary tract infections
  • Diarrhea
  • Nausea
  • Increased urination
  • Ketoacidosis
  • Lactic acidosis
  • Dehydration

Frequently Asked Questions about Xigduo XR

What is Xigduo XR used for?

Xigduo XR is used to help control blood sugar levels in adults with type 2 diabetes, along with diet and exercise.

How does Xigduo XR work?

It combines dapagliflozin, which helps remove excess sugar through urine, and metformin, which reduces sugar production in the liver.

Can Xigduo XR cause weight loss?

Some people may experience modest weight loss while taking Xigduo XR, mainly due to the action of dapagliflozin.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up doses.

Is Xigduo XR safe for people with kidney problems?

Xigduo XR should not be used in people with severe kidney impairment or end-stage renal disease. Kidney function should be monitored regularly.

What are the signs of lactic acidosis?

Symptoms include rapid breathing, severe drowsiness, muscle pain, stomach pain, and irregular heartbeat. Seek emergency help if these occur.

Can I take Xigduo XR with other diabetes medicines?

Yes, but your doctor may need to adjust your doses to prevent low blood sugar or other side effects. Always consult your healthcare provider.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.