Xenleta (lefamulin) — Uses, Dosage, Side Effects & Safety

Drug class: Antibiotic (Pleuromutilin class)

Overview

Xenleta (lefamulin) is a prescription antibiotic used to treat adults with community-acquired bacterial pneumonia (CABP). It works by stopping the growth of certain bacteria that cause lung infections. Xenleta belongs to a newer class of antibiotics called pleuromutilins, which target bacterial protein synthesis in a unique way. This medication is effective against a range of bacteria, including some strains that may be resistant to other antibiotics. Xenleta is available as tablets or as an intravenous (IV) infusion, and your doctor will decide which form is best for you. It is important to complete the full course of treatment, even if you start to feel better, to ensure the infection is fully cleared.

Therapeutic uses

  • Community-acquired bacterial pneumonia (CABP)

Common side effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • QT prolongation
  • Clostridioides difficile-associated diarrhea
  • Hypersensitivity reactions

Frequently Asked Questions about Xenleta

What is Xenleta used for?

Xenleta is used to treat adults with community-acquired bacterial pneumonia (CABP), a type of lung infection caused by certain bacteria.

How does Xenleta work?

Xenleta works by blocking bacterial protein synthesis, which stops the bacteria from growing and multiplying. This helps your body fight the infection.

Can I take Xenleta if I have liver disease?

If you have liver disease, your doctor may need to adjust your dose or monitor you more closely. Severe liver impairment is a contraindication for Xenleta.

Is Xenleta safe during pregnancy or breastfeeding?

Xenleta is not recommended during pregnancy or breastfeeding unless the benefits outweigh the risks. Discuss with your doctor if you are pregnant or nursing.

What should I do if I experience severe diarrhea while taking Xenleta?

Contact your doctor immediately, as severe diarrhea may be a sign of a serious intestinal infection (C. difficile-associated diarrhea).

Can children take Xenleta?

Xenleta is not approved for use in children under 18 years of age.

Are there any foods or drinks I should avoid while taking Xenleta?

Take oral Xenleta tablets at least 1 hour before or 2 hours after eating. Avoid alcohol and grapefruit products, as they may increase side effects or affect drug levels.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.