Voclosporin (voclosporin) — Uses, Dosage, Side Effects & Safety

Drug class: Calcineurin inhibitor immunosuppressant

Overview

Voclosporin is a prescription medicine used to treat adults with active lupus nephritis, a serious kidney inflammation caused by systemic lupus erythematosus (SLE). It is usually prescribed in combination with other immunosuppressive therapies to help reduce kidney inflammation and prevent further kidney damage. Voclosporin works by suppressing the immune system, specifically by inhibiting calcineurin, an enzyme involved in activating immune cells. This helps reduce the abnormal immune response that leads to kidney inflammation in lupus nephritis. Key points for patients: Voclosporin can lower your body’s ability to fight infections, so it’s important to watch for signs of infection and report them to your doctor. Regular blood tests are needed to monitor kidney function and drug levels. Always take this medication exactly as prescribed and do not stop without consulting your healthcare provider.

Therapeutic uses

  • Lupus nephritis

Common side effects

  • Hypertension
  • Kidney impairment
  • Headache
  • Diarrhea
  • Tremor
  • Urinary tract infection
  • Anemia

Frequently Asked Questions about Voclosporin

What is voclosporin used for?

Voclosporin is used to treat active lupus nephritis in adults, helping to reduce kidney inflammation and prevent further damage.

How does voclosporin work?

Voclosporin works by inhibiting calcineurin, which suppresses the immune system and reduces the abnormal immune response in lupus nephritis.

What are the most common side effects of voclosporin?

Common side effects include headache, high blood pressure, diarrhea, nausea, and decreased kidney function.

Can I take voclosporin if I am pregnant or breastfeeding?

Voclosporin is not recommended during pregnancy or breastfeeding unless clearly needed. Discuss risks and benefits with your doctor.

Are there foods or medicines I should avoid while taking voclosporin?

Avoid grapefruit products and live vaccines. Inform your doctor about all other medicines and supplements you are taking.

How long will I need to take voclosporin?

The duration of treatment depends on your response and your doctor’s recommendation. Do not stop taking it without consulting your healthcare provider.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up doses.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.