Vismodegib (vismodegib) — Uses, Dosage, Side Effects & Safety

Drug class: Hedgehog pathway inhibitor (antineoplastic agent)

Overview

Vismodegib is a prescription medicine used to treat adults with advanced basal cell carcinoma (BCC), a type of skin cancer, when surgery or radiation is not an option or if the cancer has spread to other parts of the body. It works by blocking a specific pathway (the Hedgehog signaling pathway) that helps cancer cells grow. By interfering with this pathway, vismodegib helps slow or stop the growth of cancer cells. Patients should know that vismodegib is taken by mouth, usually once daily, and treatment may continue as long as it is effective and tolerated. Women who are pregnant or may become pregnant must not take vismodegib, as it can cause severe birth defects. Regular monitoring and follow-up with your healthcare provider are important during treatment. Common side effects include muscle spasms, hair loss, and changes in taste.

Therapeutic uses

  • Basal cell carcinoma, locally advanced
  • Basal cell carcinoma, metastatic

Common side effects

  • Muscle spasms
  • Alopecia
  • Dysgeusia
  • Weight loss
  • Nausea
  • Fatigue
  • Diarrhea
  • Amenorrhea

Frequently Asked Questions about Vismodegib

What is vismodegib used for?

Vismodegib is used to treat adults with advanced basal cell carcinoma (BCC) when surgery or radiation is not suitable, or if the cancer has spread.

How does vismodegib work?

Vismodegib blocks the Hedgehog signaling pathway, which is involved in the growth of certain cancer cells, helping to slow or stop tumor growth.

Can vismodegib be used during pregnancy?

No. Vismodegib can cause severe birth defects and must not be used during pregnancy. Effective contraception is required for women and men during and after treatment.

What are the most common side effects?

The most common side effects include muscle spasms, hair loss, changes in taste, fatigue, nausea, diarrhea, and decreased appetite.

How long do I need to take vismodegib?

You should take vismodegib as long as your doctor recommends, usually until the cancer progresses or side effects become intolerable.

What should I do if I miss a dose?

If you miss a dose, skip it and take your next dose at the usual time. Do not double up doses.

Are there any foods or medicines I should avoid?

Avoid St. John's Wort and other strong CYP enzyme inducers, as they may reduce the effectiveness of vismodegib. Discuss all medications and supplements with your healthcare provider.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.