Velpatasvir — Uses, Dosage, Side Effects & Safety

Drug class: Antiviral (Direct-acting antiviral, NS5A inhibitor)

Overview

Velpatasvir is an antiviral medication used in combination with sofosbuvir to treat chronic hepatitis C virus (HCV) infection in adults and children 3 years and older. It is effective against all major HCV genotypes (1-6), making it a pan-genotypic option for hepatitis C treatment. Velpatasvir works by blocking the action of a viral protein called NS5A, which is essential for the hepatitis C virus to multiply and spread in the body. By stopping the virus from replicating, velpatasvir helps clear the infection from the bloodstream. Key points for patients: Velpatasvir is not used alone—it is always combined with sofosbuvir. Most people take it once daily for 12 weeks. It is important to take the medication exactly as prescribed and to complete the full course, even if you feel well before finishing. Missing doses or stopping early can reduce the chance of cure.

Frequently Asked Questions about Velpatasvir

What is velpatasvir used for?

Velpatasvir is used in combination with sofosbuvir to treat chronic hepatitis C infection in adults and children 3 years and older. It is effective against all major HCV genotypes.

How long do I need to take velpatasvir?

Most people take velpatasvir (with sofosbuvir) once daily for 12 weeks. Your doctor may adjust the duration based on your liver condition and previous treatments.

Can I take velpatasvir if I have kidney problems?

Velpatasvir can be used in patients with mild to moderate kidney impairment. In severe renal impairment or dialysis, consult your specialist, as safety data are limited.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up doses.

Are there any foods or medicines I should avoid?

Avoid antacids within 4 hours of taking velpatasvir, and do not use St. John’s wort or rifampin. Always check with your doctor before starting new medicines.

Can velpatasvir cure hepatitis C?

When taken as prescribed with sofosbuvir, velpatasvir can cure hepatitis C in most people. Cure rates are typically over 95% for all genotypes.

Is it safe to use velpatasvir during pregnancy or breastfeeding?

There is limited data on velpatasvir use in pregnancy and breastfeeding. Use only if clearly needed and after discussing risks and benefits with your doctor.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.