Ustekinumab (Stelara) (ustekinumab) — Uses, Dosage, Side Effects & Safety

Drug class: Monoclonal antibody; Immunosuppressant; Interleukin inhibitor

Overview

Ustekinumab (Stelara) is a prescription medicine used to treat moderate to severe plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis in adults and some children. It works by targeting specific proteins in the immune system (interleukin-12 and interleukin-23) that cause inflammation, helping to reduce symptoms and prevent flare-ups. This medication is given as an injection under the skin or into a vein, usually by a healthcare professional. Ustekinumab can help improve skin, joint, and digestive symptoms, but it may take several weeks to notice full benefits. Key points: Ustekinumab lowers immune activity, so it can increase the risk of infections. Regular monitoring and follow-up with your doctor are important. Always inform your healthcare provider about any infections, vaccinations, or other medications you are taking.

Frequently Asked Questions about Ustekinumab (Stelara)

What conditions does ustekinumab (Stelara) treat?

Ustekinumab is used to treat moderate to severe plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis in adults and some children.

How long does it take for ustekinumab to work?

Some people notice improvement within a few weeks, but full benefits may take up to 12–16 weeks, depending on the condition.

Can I get vaccines while on ustekinumab?

You should not receive live vaccines while on ustekinumab. Inactivated vaccines are generally safe but discuss with your doctor first.

What should I do if I develop an infection while taking ustekinumab?

Contact your healthcare provider immediately if you develop signs of infection, such as fever, cough, or sore throat.

Is ustekinumab safe during pregnancy or breastfeeding?

There is limited data on safety in pregnancy and breastfeeding. Discuss risks and benefits with your doctor before starting treatment.

Can ustekinumab be self-injected at home?

Yes, after proper training by a healthcare provider, some patients may self-inject at home. Always follow your provider’s instructions.

What are the most serious risks of ustekinumab?

Serious risks include severe infections, allergic reactions, and a possible increased risk of certain cancers.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.