Uridine triacetate (Xuriden)
Pronunciation: (YOOR-i-deen try-AS-eh-tate).
- Generic name
- uridine triacetate
- Brand names
- Xuriden
- Drug class
- Uridine replacement (pyrimidine analog)
- Legal status
- Prescription-only
Availability and supply rules vary by country
Trade names by country: United States
Australia: · Full directory
What uridine triacetate is and how it works
Xuriden (uridine triacetate) is a prescription uridine replacement for hereditary orotic aciduria, a very rare inherited disorder in which the body cannot make enough uridine, a building block of RNA. Taken once daily as oral granules mixed with soft food or milk, it supplies the uridine the body is missing. Treatment is managed lifelong by a metabolic specialist. In its clinical trials for this condition, no adverse reactions were reported, and the label lists no contraindications or warnings — an unusually clean safety profile that reflects uridine being a natural substance the body already uses. (1)
What uridine triacetate is used for
Hereditary orotic aciduria
Uridine replacement therapy in adult and pediatric patients with hereditary orotic aciduria, managed by a metabolic specialist. (1)
Before taking uridine triacetate
Do not take / not appropriate for
- The label lists no contraindications for Xuriden. () (1)
Tell your clinician about
(1)How to take uridine triacetate
- Taken once daily; the dose is calculated by body weight (starting 60 mg/kg) by the metabolic specialist.
- Measure the prescribed amount of granules and mix with soft food such as applesauce, pudding, or yogurt, or give in milk or infant formula, then take right away.
- If the response is insufficient, the specialist can prescribe up to 120 mg/kg (not exceeding 8 grams) once daily.
Procedures and treatment changes
Tell the treating team before surgery, procedures, or any medicine change. Do not alter treatment without the responsible clinician. (1)
Missed dose
The label does not give specific missed-dose instructions. Ask the metabolic specialist or pharmacist what to do about a missed day rather than changing the amount yourself.
Overdose
No overdose management is described in the label. Contact a poison-information service or the metabolic team for advice if much more than the prescribed amount is taken. (1)
Side effects
Side effects and their urgency vary; report severe, persistent, or concerning symptoms.
None reported in clinical trials
What to notice: The label states that no adverse reactions were reported in the Xuriden trials for hereditary orotic aciduria.
What to do: Report any new or unusual symptom to the metabolic team anyway — trial populations for very rare diseases are small. (1)
What to watch when combined with digoxin
What to notice: Laboratory studies showed uridine triacetate can inhibit digoxin transport (P-glycoprotein); symptoms of high digoxin include nausea, visual changes, or irregular heartbeat.
What to do: The specialist reviews digoxin co-use and monitoring; report those symptoms promptly if you also take digoxin. (1)
Any unexpected reaction after dosing
What to notice: Rash, swelling, breathing difficulty, or any new symptom that concerns you.
What to do: Contact the metabolic team promptly; seek emergency care for facial or throat swelling or trouble breathing. (1)
Serious warnings
No warnings listed in the label — informational
Symptoms: The FDA label for Xuriden lists no warnings or precautions, and clinical trials in hereditary orotic aciduria reported no adverse reactions.
Action: Even so, report anything unusual after doses to the metabolic team — rare-disease trials involve small numbers of patients, and the specialist tracks each patient closely. (1)
Interactions
| Medicine or test | Effect | Action |
|---|---|---|
| Digoxin (P-glycoprotein substrate) | Uridine triacetate is a weak P-gp substrate and inhibited digoxin transport in vitro — digoxin levels could rise. | Tell the specialist if you take digoxin; they decide on monitoring. (1) |
| Other medicines | No meaningful CYP-enzyme inhibition or induction was observed in studies. | Still give the care team a complete medicine list for review. (1) |
Pregnancy, breastfeeding, kidney/liver function, age
Pregnancy
Animal studies at about 2.7 times the maximum recommended human dose showed no teratogenicity; there are no human data — the decision is made with the specialist. (1)
Breastfeeding
There are no data on uridine triacetate in human milk; the decision weighs the benefit of treatment and of breastfeeding with the care team. (1)
Children
Approved for pediatric patients; dosing is weight-based and set by the metabolic specialist. (1)
Kidney_impairment
No renal dosing guidance is given in the label; the specialist individualizes care. (1)
Liver_impairment
No hepatic dosing guidance is given in the label; the specialist individualizes care. (1)
Monitoring
Before starting
- Confirmation of the diagnosis of hereditary orotic aciduria by the metabolic team
- Full medicine review, including digoxin
During treatment
- Ongoing metabolic-specialist follow-up of growth, blood counts, and urinary orotic acid as the specialist directs
- Dose reviews against weight, with increases up to 120 mg/kg daily decided by the specialist
Storage
Store at controlled room temperature, 25°C (77°F), with excursions permitted between 15–30°C (59–86°F). Keep out of reach of children.
Professional information
Clinician-facing context only. This section does not replace current product labeling.
United States
Indication: Hereditary orotic aciduria (uridine replacement)
Dose summary: Start 60 mg/kg orally once daily (granules in soft food or milk/formula); may increase to 120 mg/kg once daily (max 8 g/day) for insufficient efficacy — plasma/urine orotic acid and clinical response guide titration.
Renal context: No renal or hepatic dose adjustments are provided in the label; individualize. Weak P-gp substrate; inhibited digoxin transport in vitro — review digoxin co-administration. (1)
Frequently asked questions
What is hereditary orotic aciduria?
A very rare inherited disorder of pyrimidine synthesis: the body cannot produce enough uridine, which is needed to build RNA. Xuriden supplies uridine directly, and treatment continues lifelong under a metabolic specialist. (1)
How is the dose taken?
Once daily, measured by body weight (starting at 60 mg/kg). The granules are mixed into applesauce, pudding, or yogurt, or given in milk or infant formula, and taken straight away. (1)
Does Xuriden have side effects?
The label reports no adverse reactions in its clinical trials for this condition, and lists no warnings or contraindications. Because rare-disease trials are small, anything unusual should still be reported to the specialist team. (1)
Is this the same medicine used for chemotherapy overdose?
The same molecule is marketed separately as Vistogard for 5-fluorouracil or capecitabine overdose, with different dosing. This page covers only Xuriden and hereditary orotic aciduria. (1)
What is the generic name of Uridine triacetate (Xuriden)?
The generic name is uridine triacetate. It is sold under brand names including Xuriden.
What class of drug is uridine triacetate?
Uridine triacetate (Xuriden) is classed as: Uridine replacement (pyrimidine analog).
References
- XURIDEN (uridine triacetate) oral granules — prescribing informationU.S. National Library of Medicine DailyMed · United States · dated 2023-08 · accessed 2026-08-08 · source 1
- VISTOGARD (URIDINE TRIACETATE) GRANULE [BTG INTERNATIONAL INC] — US prescribing information (DailyMed SPL)U.S. National Library of Medicine (DailyMed) · US · accessed 2026-08-14 · source 2
- Uridine Triacetate — patient drug information (MedlinePlus)U.S. National Library of Medicine (MedlinePlus) · US · accessed 2026-08-14 · source 3
- VISTOGARD — FDA approval record (Drugs@FDA NDA208159)U.S. Food and Drug Administration · US · accessed 2026-08-14 · source 4
- uridine triacetate — RxNorm normalized drug concept (RXCUI 1665222)U.S. National Library of Medicine (RxNorm) · US · accessed 2026-08-14 · source 5
Brand names by country
Single-ingredient uridine triacetate names are shown separately by country. Product availability, strengths, and supply rules can change; combination products are not included here.
Priority countries
United States
- XURIDEN951 mg/g · btg international inc
- VISTOGARD951 mg/g · btg international inc