Uridine triacetate — Uses, Dosage, Side Effects & Safety

Drug class: Addiction & Toxicology

Overview

Uridine triacetate is a medication used as an emergency antidote to treat life-threatening toxicity or overdose caused by fluorouracil (5-FU) or capecitabine, which are chemotherapy drugs. It is also prescribed for hereditary orotic aciduria, a rare genetic disorder. Uridine triacetate works by providing uridine, a natural substance that helps protect healthy cells from the toxic effects of certain chemotherapy drugs. By restoring uridine levels, it helps prevent or reverse severe side effects from 5-FU or capecitabine. Key points: This medicine must be started as soon as possible after overdose or severe toxicity symptoms appear, ideally within 96 hours. It is taken by mouth as granules mixed with soft food. Always follow your healthcare provider's instructions closely.

Therapeutic uses

  • Hereditary orotic aciduria
  • Fluorouracil overdose
  • Capecitabine overdose

Common side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Anemia
  • Neutropenia
  • Thrombocytopenia

Frequently Asked Questions about Uridine triacetate

What is uridine triacetate used for?

It is used as an emergency antidote for overdose or severe toxicity from fluorouracil (5-FU) or capecitabine chemotherapy, and for treating hereditary orotic aciduria.

How quickly should uridine triacetate be started after overdose?

It should be started as soon as possible, ideally within 96 hours (4 days) of the last dose of 5-FU or capecitabine.

How do I take uridine triacetate granules?

Mix the granules with soft food and swallow without chewing, following your healthcare provider's instructions.

Can children take uridine triacetate?

Yes, pediatric dosing is available and is based on body surface area. Always follow your doctor’s guidance.

What should I do if I vomit after taking a dose?

If vomiting occurs within 2 hours of a dose, take another full dose as soon as possible. Contact your healthcare provider for further instructions.

Are there any serious side effects?

Serious side effects are rare but may include severe allergic reactions, persistent vomiting or diarrhea, and signs of infection. Seek medical help if these occur.

Is uridine triacetate available in Australia?

Yes, uridine triacetate (Vistogard) is available in Australia. For more information, consult the TGA or your healthcare provider.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.