Uridine — Uses, Dosage, Side Effects & Safety

Drug class: Nucleoside analog; Pyrimidine nucleoside

Overview

Uridine is a naturally occurring nucleoside used as a medication primarily to treat hereditary orotic aciduria, a rare metabolic disorder. It may also be used as an adjunct in certain chemotherapy overdoses and is being studied for its potential benefits in neurological and mitochondrial disorders. Uridine works by providing the body with a source of pyrimidine, which is essential for the synthesis of RNA and DNA. In hereditary orotic aciduria, uridine supplementation bypasses the metabolic block, reducing orotic acid levels and improving symptoms. Key points for patients: Uridine is generally well tolerated, but it should be taken exactly as prescribed. It is important to inform your healthcare provider about all medications and supplements you are taking, as interactions may occur.

Therapeutic uses

  • Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome
  • Hereditary orotic aciduria
  • Chemotherapy-induced peripheral neuropathy (off-label)
  • Hepatitis C (in combination with other antivirals, historically)

Common side effects

  • Headache
  • Nausea
  • Diarrhea
  • Fatigue
  • Insomnia
  • Rash
  • Abdominal pain

Frequently Asked Questions about Uridine

What is uridine used for?

Uridine is primarily used to treat hereditary orotic aciduria, a rare genetic disorder. It is also used as an antidote for certain chemotherapy overdoses and is being studied for neurological and mitochondrial disorders.

How should I take uridine?

Take uridine exactly as prescribed by your doctor, usually once daily. It can be taken with or without food. Follow your healthcare provider's instructions carefully.

What are the common side effects of uridine?

Common side effects include mild nausea, vomiting, diarrhea, headache, and abdominal discomfort. Most people tolerate uridine well.

Can uridine be used in children?

Yes, uridine can be used in children for approved indications, with dosing adjusted by weight and under medical supervision.

Is uridine safe during pregnancy or breastfeeding?

The safety of uridine during pregnancy or breastfeeding is not well established. Use only if clearly needed and prescribed by your doctor.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double up to make up for a missed dose.

Are there any drug interactions with uridine?

Uridine may interact with certain chemotherapy drugs, especially fluorouracil (5-FU). Always inform your healthcare provider of all medications and supplements you are taking.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.