Uptravi (Selexipag) (Selexipag) — Uses, Dosage, Side Effects & Safety

Drug class: Selective Prostacyclin Receptor Agonist (Prostacyclin Pathway Agent)

Overview

Uptravi (Selexipag) is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH, WHO Group 1). PAH is a rare, progressive disease characterized by high blood pressure in the arteries of the lungs, which can lead to shortness of breath, fatigue, chest pain, and heart failure if untreated. Uptravi works by targeting the prostacyclin pathway. It selectively activates the prostacyclin (IP) receptor, helping to relax and widen the blood vessels in the lungs. This reduces the pressure in the pulmonary arteries and improves the ability to exercise and perform daily activities. Key points for patients: Uptravi is taken by mouth, usually twice daily, and dosing is gradually increased to the highest tolerated dose. It is important to take this medication exactly as prescribed and not to stop suddenly without consulting your healthcare provider.

Frequently Asked Questions about Uptravi (Selexipag)

What is Uptravi (Selexipag) used for?

Uptravi is used to treat pulmonary arterial hypertension (PAH) in adults to improve exercise capacity and delay disease progression.

How does Uptravi work?

Uptravi selectively activates the prostacyclin (IP) receptor, helping to relax and widen blood vessels in the lungs, reducing blood pressure and improving symptoms.

What are the most common side effects?

Common side effects include headache, diarrhea, jaw pain, nausea, muscle pain, flushing, and pain in the arms or legs.

Can I take Uptravi if I have liver or kidney disease?

Uptravi should be used with caution in patients with liver or kidney impairment. It is contraindicated in severe liver impairment. Dose adjustments may be needed.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up. If you miss more than three days, consult your doctor before restarting.

Is Uptravi safe during pregnancy or breastfeeding?

Uptravi is not recommended during pregnancy unless clearly needed. The safety in breastfeeding is unknown; consult your doctor for guidance.

Can I take other PAH medications with Uptravi?

Uptravi may be used in combination with other PAH therapies, but your doctor will monitor for interactions and side effects.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.