Uplizna (inebilizumab-cdon) — Uses, Dosage, Side Effects & Safety

Drug class: Monoclonal antibody; Immunosuppressant

Overview

Uplizna is a prescription medicine used to treat adults with neuromyelitis optica spectrum disorder (NMOSD) who are anti-aquaporin-4 (AQP4) antibody positive. NMOSD is a rare autoimmune disease that affects the optic nerves and spinal cord, leading to symptoms such as vision loss, muscle weakness, and pain. Uplizna works by targeting and depleting specific immune cells (B cells) that are believed to play a key role in the inflammation and nerve damage seen in NMOSD. By reducing these cells, Uplizna helps lower the risk of disease relapses and progression. Key points for patients: Uplizna is given as an intravenous infusion under medical supervision, usually every 6 months after initial loading doses. It is important to attend all scheduled infusions and follow-up appointments. Patients should report any signs of infection or unusual symptoms to their healthcare provider promptly.

Therapeutic uses

  • Neuromyelitis optica spectrum disorder (NMOSD)

Common side effects

  • Infusion-related reactions
  • Urinary tract infection
  • Arthralgia
  • Headache
  • Serious infections
  • Progressive multifocal leukoencephalopathy (PML)
  • Hypogammaglobulinemia

Frequently Asked Questions about Uplizna

What is Uplizna used for?

Uplizna is used to treat adults with neuromyelitis optica spectrum disorder (NMOSD) who are anti-AQP4 antibody positive. It helps reduce the risk of disease relapses.

How is Uplizna administered?

Uplizna is given as an intravenous infusion by a healthcare professional. The first two doses are given two weeks apart, followed by maintenance infusions every six months.

What are the most common side effects of Uplizna?

The most common side effects include urinary tract infections, joint pain, infusion-related reactions, and back pain.

Can I receive vaccines while on Uplizna?

Live or live-attenuated vaccines should be avoided during and after Uplizna treatment. Discuss vaccination plans with your healthcare provider before starting therapy.

Is Uplizna safe during pregnancy or breastfeeding?

There is limited data on the use of Uplizna in pregnancy or breastfeeding. Discuss risks and benefits with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

What should I do if I miss a dose?

Contact your healthcare provider as soon as possible to reschedule a missed infusion. Do not attempt to self-administer or change the schedule on your own.

Are there any long-term risks with Uplizna?

Long-term risks may include increased susceptibility to infections and possible risk of rare brain infections (PML). Regular monitoring and follow-up with your healthcare provider are important.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.