Ulipristal acetate — Uses, Dosage, Side Effects & Safety

Drug class: Selective Progesterone Receptor Modulator (SPRM)

Overview

Ulipristal acetate is a prescription medication used primarily for emergency contraception (to prevent pregnancy after unprotected sex or contraceptive failure) and for the treatment of moderate to severe symptoms of uterine fibroids in adult women. As an emergency contraceptive, it is most effective when taken as soon as possible within 120 hours (5 days) after unprotected intercourse. Ulipristal acetate works by modifying the activity of the body’s natural hormone progesterone. It delays or inhibits ovulation and may also alter the lining of the uterus, making it less suitable for implantation. For fibroid treatment, it reduces the size of fibroids and controls heavy menstrual bleeding. Key points: Ulipristal acetate does not terminate an existing pregnancy and should not be used as a regular contraceptive. It is not effective if you are already pregnant. Always use as directed by a healthcare professional.

Frequently Asked Questions about Ulipristal acetate

How effective is ulipristal acetate for emergency contraception?

Ulipristal acetate is highly effective when taken within 120 hours (5 days) after unprotected sex, with efficacy rates higher than levonorgestrel-based emergency contraceptives, especially closer to ovulation.

Can I use ulipristal acetate if I am breastfeeding?

Ulipristal acetate passes into breast milk. It is recommended to avoid breastfeeding for one week after taking the medication for emergency contraception.

What should I do if I vomit after taking ulipristal acetate?

If you vomit within 3 hours of taking the tablet, contact your healthcare provider. You may need to take another dose.

Can ulipristal acetate be used as a regular contraceptive?

No, ulipristal acetate is not intended for regular contraception. It should only be used for emergency situations or as prescribed for fibroid treatment.

Are there any long-term risks with repeated use?

Repeated use for emergency contraception within the same menstrual cycle is not recommended. For fibroid treatment, liver function monitoring is required due to risk of liver injury.

Does ulipristal acetate interact with other medications?

Yes, especially with CYP3A4 inducers (e.g., rifampin, phenytoin, St. John’s wort) and hormonal contraceptives. Always check with your healthcare provider.

What should I do if my period is late after taking ulipristal acetate?

If your period is more than 7 days late, or if you have symptoms of pregnancy, take a pregnancy test and consult your healthcare provider.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.