Trifluridine — Uses, Dosage, Side Effects & Safety

Drug class: Antiviral (Nucleoside analog)

Overview

Trifluridine is an antiviral medication primarily used to treat eye infections caused by the herpes simplex virus, such as herpes simplex keratitis (an infection of the cornea). It is available as an ophthalmic solution (eye drops) and, in combination with tipiracil, as an oral tablet for certain types of cancer. Trifluridine works by interfering with the DNA replication of viruses, stopping their ability to multiply and spread. When used as eye drops, it helps clear up viral infections in the eye and reduces symptoms like redness, pain, and swelling. Key points: Use the medication exactly as prescribed, complete the full course even if symptoms improve, and avoid touching the tip of the dropper to prevent contamination. If you wear contact lenses, remove them before using the drops and wait at least 15 minutes before reinserting.

Frequently Asked Questions about Trifluridine

What is trifluridine used for?

Trifluridine is primarily used to treat eye infections caused by the herpes simplex virus, such as herpes simplex keratitis. In combination with tipiracil, it is also used orally to treat certain types of metastatic colorectal cancer.

How quickly does trifluridine work?

Improvement in symptoms is usually seen within a few days of starting treatment, but it is important to complete the full course as prescribed to ensure the infection is fully treated.

Can I use trifluridine if I wear contact lenses?

You should remove contact lenses before using trifluridine eye drops and wait at least 15 minutes before reinserting them. Do not wear contact lenses if your eye is red or infected unless your doctor advises otherwise.

What should I do if I experience severe eye pain or vision changes?

Stop using the medication and contact your healthcare provider immediately if you experience severe eye pain, vision changes, or signs of a serious allergic reaction.

Is trifluridine safe during pregnancy or breastfeeding?

The safety of trifluridine during pregnancy or breastfeeding is not fully established. Use only if clearly needed and prescribed by your doctor.

Can trifluridine be used in children?

Trifluridine can be used in children for certain indications, but dosing should be determined by a healthcare provider.

What should I do if I accidentally ingest trifluridine eye drops?

If trifluridine eye drops are accidentally swallowed, seek medical attention or contact a poison control center immediately, especially if you experience unusual symptoms.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.