Selegiline (selegiline) — Uses, Dosage, Side Effects & Safety

Drug class: Monoamine oxidase type B (MAO-B) inhibitor

Overview

Selegiline is a medication primarily used to treat symptoms of Parkinson’s disease, either alone or in combination with other drugs such as levodopa/carbidopa. It may also be prescribed for major depressive disorder in its transdermal patch form. Selegiline works by selectively inhibiting the enzyme monoamine oxidase type B (MAO-B) in the brain. This helps increase and prolong the action of dopamine, a neurotransmitter that is often deficient in people with Parkinson’s disease. By preserving dopamine, selegiline can help improve movement, reduce tremors, and decrease muscle stiffness. Key points for patients: Selegiline does not cure Parkinson’s disease but can help manage symptoms. It is important to take this medication exactly as prescribed and to be aware of potential interactions with certain foods and other medications.

Therapeutic uses

  • Parkinson's disease (adjunctive therapy)
  • Major depressive disorder (transdermal patch)
  • Dementia (off-label, limited evidence)

Common side effects

  • Nausea
  • Dizziness
  • Insomnia
  • Headache
  • Orthostatic hypotension
  • Hallucinations
  • Serotonin syndrome

Frequently Asked Questions about Selegiline

What is selegiline used for?

Selegiline is primarily used to manage symptoms of Parkinson’s disease and, in its patch form, to treat major depressive disorder.

How does selegiline work?

Selegiline selectively inhibits the MAO-B enzyme in the brain, which helps increase dopamine levels and improve movement symptoms in Parkinson’s disease.

Can I take selegiline with other Parkinson’s medications?

Yes, selegiline is often used in combination with levodopa/carbidopa. However, always consult your doctor before combining medications.

What foods should I avoid while taking selegiline?

At standard doses for Parkinson’s disease, dietary restrictions are usually not necessary. However, at higher doses or with the patch, avoid foods high in tyramine (aged cheeses, cured meats, fermented foods) to prevent hypertensive crisis.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up doses.

Are there any serious side effects I should watch for?

Yes. Seek immediate medical help if you experience chest pain, severe headache, confusion, hallucinations, or signs of serotonin syndrome.

Is selegiline safe during pregnancy or breastfeeding?

The safety of selegiline in pregnancy and breastfeeding is not well established. Discuss risks and benefits with your healthcare provider.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.