Roxadustat (roxadustat) — Uses, Dosage, Side Effects & Safety

Drug class: Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)

Overview

Roxadustat is a prescription medication used to treat anemia (low red blood cell count) in adults with chronic kidney disease (CKD), whether or not they are on dialysis. Anemia is common in CKD and can cause fatigue, weakness, and shortness of breath. Roxadustat works by stimulating your body to produce more of its own erythropoietin, a natural hormone that helps make red blood cells. It does this by blocking certain enzymes (prolyl hydroxylases), which increases the production of red blood cells and helps improve oxygen delivery throughout your body. Key points: Roxadustat is taken by mouth, usually three times a week. It is important to follow your doctor’s instructions closely and attend regular blood tests to monitor your response and check for side effects.

Therapeutic uses

  • Anemia of chronic kidney disease (CKD) in adult patients on dialysis
  • Anemia of chronic kidney disease (CKD) in adult patients not on dialysis

Common side effects

  • Hypertension
  • Thrombosis
  • Nausea
  • Diarrhea
  • Peripheral edema
  • Hyperkalemia
  • Deep vein thrombosis

Frequently Asked Questions about Roxadustat

What is Roxadustat used for?

Roxadustat is used to treat anemia in adults with chronic kidney disease, both on dialysis and not on dialysis.

How does Roxadustat work?

It increases your body’s natural production of erythropoietin, which stimulates the bone marrow to make more red blood cells.

What are the most common side effects?

Common side effects include headache, nausea, diarrhea, high blood pressure, and swelling.

Can Roxadustat be used in children?

No, Roxadustat is not approved for use in children. Safety and efficacy have not been established in pediatric patients.

How should I take Roxadustat?

Take it exactly as prescribed, usually three times per week, with or without food. Swallow the tablet whole with water.

What should I do if I miss a dose?

Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double up doses.

Are there any foods or medicines I should avoid?

Avoid grapefruit and grapefruit juice, and do not take iron supplements or phosphate binders at the same time unless directed by your doctor.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.