Regorafenib (regorafenib) — Uses, Dosage, Side Effects & Safety

Drug class: Multikinase inhibitor (anticancer agent)

Overview

Regorafenib is a targeted cancer medicine used to treat certain types of advanced cancers, including colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (liver cancer) when other treatments have not worked or are no longer effective. It works by blocking multiple enzymes (kinases) that promote cancer cell growth and help tumors develop new blood vessels (angiogenesis). Patients should know that regorafenib is taken by mouth as a tablet, usually once daily for 3 weeks followed by 1 week off in a 4-week cycle. It is important to take the medication exactly as prescribed and to report any side effects, especially severe ones, to your healthcare provider.

Therapeutic uses

  • Metastatic colorectal cancer
  • Gastrointestinal stromal tumors (GIST)
  • Hepatocellular carcinoma

Common side effects

  • Hand-foot skin reaction
  • Diarrhea
  • Fatigue
  • Hypertension
  • Hemorrhage
  • Hepatotoxicity
  • Gastrointestinal perforation

Frequently Asked Questions about Regorafenib

What types of cancer does regorafenib treat?

Regorafenib is used for metastatic colorectal cancer, advanced gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (liver cancer) after other treatments have failed.

How long do I need to take regorafenib?

Treatment duration depends on your response and tolerance. Your doctor will monitor your progress and decide how long you should continue.

What should I do if I experience severe side effects?

Contact your doctor immediately if you experience severe side effects such as severe diarrhea, bleeding, yellowing of the skin or eyes, or chest pain.

Can I take regorafenib with food?

Take regorafenib with a low-fat meal to help with absorption and reduce stomach upset. Avoid high-fat meals.

Is regorafenib safe during pregnancy or breastfeeding?

Regorafenib is not recommended during pregnancy or breastfeeding due to potential harm to the baby. Discuss contraception and family planning with your doctor.

Are there any foods or drinks I should avoid?

Avoid grapefruit and grapefruit juice, as they can increase regorafenib levels and side effects.

How will my doctor monitor me while I am on regorafenib?

Your doctor will regularly check your liver function, blood pressure, blood counts, and for signs of bleeding or skin reactions.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.