Quinupristin injection (Quinupristin) — Uses, Dosage, Side Effects & Safety

Drug class: Streptogramin antibiotic

Overview

Quinupristin injection is an antibiotic used to treat serious infections caused by certain bacteria, especially those that are resistant to other antibiotics. It is most commonly prescribed for complicated skin and soft tissue infections and for infections caused by vancomycin-resistant Enterococcus faecium (VRE). Quinupristin is always given in combination with another antibiotic, dalfopristin, as the combination (quinupristin/dalfopristin) works more effectively than either drug alone. This medication works by stopping the growth of bacteria, helping your body fight off the infection. It is given by intravenous infusion in a hospital or clinical setting under the supervision of a healthcare professional. Patients should be aware that quinupristin injection is reserved for infections that cannot be treated with other antibiotics due to resistance or intolerance. Key points: Complete the full course as prescribed, even if you feel better. Report any side effects, especially pain or swelling at the injection site, muscle aches, or signs of an allergic reaction. This medication does not treat viral infections (such as the common cold or flu).

Therapeutic uses

  • Vancomycin-resistant Enterococcus faecium (VRE) bacteremia
  • Complicated skin and skin structure infections (cSSSI)
  • Hospital-acquired pneumonia (HAP)
  • Ventilator-associated pneumonia (VAP)

Common side effects

  • Pain, swelling, or redness at the injection site
  • Nausea
  • Vomiting
  • Diarrhea
  • Rash
  • Headache
  • Muscle and joint pain
  • Elevated liver enzymes

Frequently Asked Questions about Quinupristin injection

What infections does quinupristin injection treat?

Quinupristin injection is used to treat serious infections caused by certain resistant bacteria, including complicated skin and soft tissue infections and infections due to vancomycin-resistant Enterococcus faecium (VRE).

How is quinupristin injection administered?

It is given as an intravenous infusion by a healthcare professional, typically over at least 60 minutes.

What should I do if I experience severe pain at the injection site?

Notify your healthcare provider immediately. Severe pain, swelling, or redness may indicate a serious reaction and may require changing the infusion site or discontinuing the medication.

Can I take quinupristin injection if I have liver disease?

Quinupristin should be used with caution in patients with liver disease. Dose adjustments or alternative treatments may be necessary. Discuss your medical history with your doctor.

Are there any foods or drinks I should avoid?

Avoid alcohol while receiving quinupristin, as it may increase the risk of liver side effects. There are no specific food restrictions, but always follow your healthcare provider's advice.

Can I use quinupristin injection during pregnancy or breastfeeding?

The safety of quinupristin injection during pregnancy or breastfeeding is not well established. Use only if clearly needed and prescribed by your doctor.

What should I do if I miss a dose?

Contact your healthcare provider as soon as possible. Do not double the next dose. In hospital settings, the medical team will manage missed doses.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.