Ofatumumab — Uses, Dosage, Side Effects & Safety

Drug class: Monoclonal antibody; Anti-CD20 agent; Immunomodulator

Overview

Ofatumumab is a prescription medicine used to treat certain autoimmune and blood disorders. It is most commonly prescribed for adults with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It is also used in some cases to treat chronic lymphocytic leukemia (CLL). Ofatumumab works by targeting a protein called CD20 found on the surface of B cells, a type of white blood cell involved in immune responses. By binding to CD20, ofatumumab helps reduce the number of abnormal B cells that contribute to disease activity in MS and CLL. Key points for patients: Ofatumumab is given as an injection, usually under the skin (subcutaneous) for MS, or as an intravenous infusion for CLL. It may lower your immune system's ability to fight infections, so regular monitoring and communication with your healthcare provider are important.

Frequently Asked Questions about Ofatumumab

What conditions does ofatumumab treat?

Ofatumumab is used to treat relapsing forms of multiple sclerosis (MS) and, in some cases, chronic lymphocytic leukemia (CLL).

How is ofatumumab administered?

For MS, it is given as a subcutaneous injection, often self-administered. For CLL, it is given as an intravenous infusion by a healthcare professional.

What are the most common side effects?

Common side effects include injection site reactions, upper respiratory tract infections, headache, and fatigue.

Can I receive vaccines while on ofatumumab?

You should avoid live vaccines during treatment and for several months after stopping ofatumumab. Inactivated vaccines may be less effective.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up doses. Contact your healthcare provider for guidance.

Is ofatumumab safe during pregnancy or breastfeeding?

The safety of ofatumumab in pregnancy and breastfeeding is not well established. Discuss risks and benefits with your doctor before use.

How long does it take for ofatumumab to work?

Some patients may notice a reduction in relapses or disease activity within a few months, but full benefits may take longer. Your doctor will monitor your progress.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.