Odevixibat (odevixibat) — Uses, Dosage, Side Effects & Safety

Drug class: Ileal bile acid transporter (IBAT) inhibitor

Overview

Odevixibat is a prescription medication used to treat progressive familial intrahepatic cholestasis (PFIC), a rare inherited liver disorder that causes bile to build up in the liver, leading to liver damage and severe itching (pruritus). It is approved for use in both children and adults with PFIC. Odevixibat works by blocking a protein in the intestine called the ileal bile acid transporter (IBAT). This reduces the reabsorption of bile acids from the gut, lowering their levels in the body and helping to relieve symptoms such as itching and liver damage. Key points for patients: Odevixibat does not cure PFIC but can significantly improve symptoms and quality of life. It is taken once daily, with or without food, and should be used exactly as prescribed by your healthcare provider.

Frequently Asked Questions about Odevixibat

What is Odevixibat used for?

Odevixibat is used to treat progressive familial intrahepatic cholestasis (PFIC) in adults and children aged 3 months and older. It helps reduce bile acid levels and relieve symptoms such as severe itching.

How does Odevixibat work?

Odevixibat blocks the ileal bile acid transporter (IBAT) in the intestine, reducing the reabsorption of bile acids and lowering their levels in the body.

What are the common side effects of Odevixibat?

Common side effects include diarrhea, abdominal pain, nausea, vomiting, and changes in liver function tests.

Can Odevixibat be used in children?

Yes, Odevixibat is approved for use in children aged 3 months and older with PFIC. Dosing is based on body weight.

What should I do if I miss a dose?

Take the missed dose as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose. Do not double up doses.

Are there any serious risks with Odevixibat?

Serious risks include liver dysfunction, severe diarrhea, dehydration, and allergic reactions. Contact your doctor if you experience any severe or unusual symptoms.

Can I take Odevixibat with other medications?

Some medications, especially bile acid-binding resins and certain immunosuppressants, may interact with Odevixibat. Always inform your healthcare provider about all medicines you are taking.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.