Netupitant + Palonosetron (Akynzeo) (Netupitant and Palonosetron) — Uses, Dosage, Side Effects & Safety

Drug class: Antiemetic (NK1 receptor antagonist + 5-HT3 receptor antagonist)

Overview

Netupitant + Palonosetron (Akynzeo) is a combination medicine used to prevent nausea and vomiting caused by certain cancer chemotherapy treatments. It works by blocking the signals in the brain that trigger nausea and vomiting. Netupitant blocks neurokinin-1 (NK1) receptors, while palonosetron blocks serotonin (5-HT3) receptors. Together, they provide more effective prevention of both acute and delayed chemotherapy-induced nausea and vomiting compared to either agent alone. This medication is usually taken before chemotherapy and is not intended for ongoing daily use. Patients should follow their healthcare provider’s instructions closely and report any severe or persistent side effects.

Therapeutic uses

  • Prevention of acute chemotherapy-induced nausea and vomiting (CINV)
  • Prevention of delayed chemotherapy-induced nausea and vomiting (CINV)

Common side effects

  • Headache
  • Constipation
  • Fatigue
  • Dizziness
  • Bradycardia
  • Hypersensitivity reactions
  • QT prolongation

Frequently Asked Questions about Netupitant + Palonosetron (Akynzeo)

What is Netupitant + Palonosetron (Akynzeo) used for?

It is used to prevent nausea and vomiting caused by certain chemotherapy treatments. It is not used to treat nausea or vomiting that has already started.

How does Netupitant + Palonosetron work?

Netupitant blocks NK1 receptors and palonosetron blocks 5-HT3 receptors in the brain, both of which are involved in triggering nausea and vomiting.

When should I take Akynzeo?

Take one capsule about 1 hour before your chemotherapy session, as directed by your healthcare provider.

Can I take Akynzeo with other anti-nausea medications?

Only take other anti-nausea medications if prescribed by your doctor, as combining them can increase the risk of side effects.

What should I do if I experience severe side effects?

Seek immediate medical attention if you experience symptoms such as severe allergic reactions, chest pain, or irregular heartbeat.

Is Akynzeo safe during pregnancy or breastfeeding?

The safety of Akynzeo during pregnancy or breastfeeding is not well established. Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can children use Netupitant + Palonosetron?

Safety and effectiveness in children under 18 years have not been established. Use in pediatric patients should be guided by a specialist.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.