Neratinib (neratinib) — Uses, Dosage, Side Effects & Safety

Drug class: Tyrosine kinase inhibitor (TKI), Antineoplastic agent

Overview

Neratinib is a prescription medicine used to treat adults with early-stage, HER2-positive breast cancer after they have completed treatment with trastuzumab-based therapy. It is also sometimes used for advanced or metastatic HER2-positive breast cancer in combination with other medicines. Neratinib works by blocking the activity of HER2 and other related proteins on cancer cells. This helps slow or stop the growth of cancer cells that rely on these proteins to multiply. Key points for patients: Neratinib is taken by mouth, usually once daily with food. Diarrhea is a very common side effect, so patients are often given anti-diarrheal medicines to help manage this. It is important to take Neratinib exactly as prescribed and to notify your healthcare provider if you experience severe side effects.

Frequently Asked Questions about Neratinib

What is Neratinib used for?

Neratinib is used to reduce the risk of breast cancer returning in adults with early-stage, HER2-positive breast cancer after completing trastuzumab-based therapy. It may also be used for advanced or metastatic HER2-positive breast cancer in combination with other medicines.

How should I take Neratinib?

Take Neratinib once daily with food, at the same time each day. Swallow the tablets whole with water. Do not crush, chew, or split the tablets.

What are the most common side effects?

The most common side effect is diarrhea, which can be severe. Other common side effects include nausea, vomiting, abdominal pain, fatigue, rash, and decreased appetite.

How can I manage diarrhea caused by Neratinib?

Your doctor may prescribe anti-diarrheal medicines such as loperamide to help prevent or manage diarrhea. It is important to start these medicines at the beginning of treatment and follow your doctor's instructions closely.

Can I take other medicines with Neratinib?

Some medicines can interact with Neratinib, especially those that affect stomach acid or are metabolized by CYP3A4. Always tell your doctor about all medicines and supplements you are taking.

Is Neratinib safe during pregnancy or breastfeeding?

Neratinib can harm an unborn baby and should not be used during pregnancy. Effective contraception is recommended during treatment and for at least 1 month after the last dose. Do not breastfeed while taking Neratinib and for at least 1 month after the last dose.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is less than 12 hours until your next dose. If it is less than 12 hours, skip the missed dose and take your next dose at the regular time. Do not double up doses.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.