Natalizumab (natalizumab) — Uses, Dosage, Side Effects & Safety

Drug class: Monoclonal antibody; Immunomodulator

Overview

Natalizumab is a prescription medicine used to treat adults with relapsing forms of multiple sclerosis (MS) and moderate to severe Crohn’s disease when other treatments have not worked well enough or are not tolerated . It works by blocking certain immune cells from entering the brain and spinal cord, helping to reduce inflammation and nerve damage in MS, and by reducing inflammation in the gut for Crohn’s disease . Natalizumab is given as an intravenous (IV) infusion, usually every 4 weeks, in a healthcare setting. It is important for patients to know that while natalizumab can help reduce relapses and slow disease progression, it may increase the risk of serious infections, including a rare brain infection called progressive multifocal leukoencephalopathy (PML) . Regular monitoring and communication with your healthcare provider are essential during treatment.

Frequently Asked Questions about Natalizumab

What is natalizumab used for?

Natalizumab is used to treat relapsing forms of multiple sclerosis (MS) and moderate to severe Crohn’s disease in adults who have not responded well to other treatments .

How is natalizumab administered?

It is given as an intravenous (IV) infusion by a healthcare professional, usually every 4 weeks .

What are the most serious risks of natalizumab?

The most serious risk is progressive multifocal leukoencephalopathy (PML), a rare brain infection. Other risks include severe allergic reactions and increased risk of infections .

Can I receive vaccines while on natalizumab?

You should avoid live vaccines during treatment and for several months after stopping natalizumab. Discuss all vaccines with your healthcare provider .

Is natalizumab safe during pregnancy or breastfeeding?

The safety of natalizumab during pregnancy and breastfeeding is not fully established. Discuss risks and benefits with your healthcare provider .

What should I do if I miss a dose?

Contact your healthcare provider as soon as possible to reschedule your infusion. Do not try to self-administer or double up on doses .

How will my doctor monitor me during natalizumab treatment?

Your doctor will monitor for signs of infection, perform regular neurological assessments, and may order MRI scans to check for early signs of PML .

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.