Naltrexone (naltrexone hydrochloride) — Uses, Dosage, Side Effects & Safety

Drug class: Opioid receptor antagonist

Overview

Naltrexone is a medication used to help people who are dependent on alcohol or opioids to remain abstinent. It works by blocking the effects of opioids in the brain and reducing the pleasurable feelings associated with drinking alcohol or using opioid drugs. Naltrexone does not cause a 'high' or physical dependence, and it will not treat withdrawal symptoms. Instead, it helps reduce cravings and the risk of relapse when used as part of a comprehensive treatment plan that includes counseling and support. Key points to know: Naltrexone is not a cure for addiction but can be a valuable tool in recovery. It should only be started after opioids have been stopped for at least 7–10 days to avoid withdrawal. Regular follow-up with your healthcare provider is important to monitor progress and manage any side effects.

Frequently Asked Questions about Naltrexone

How long does naltrexone take to start working?

Naltrexone begins to block opioid receptors within 1–2 hours after oral administration. For alcohol dependence, it may take several days to notice reduced cravings.

Can I take naltrexone if I am still using opioids?

No. Starting naltrexone while opioids are in your system can cause sudden and severe withdrawal symptoms. You must be opioid-free for at least 7–10 days before starting.

Is naltrexone addictive?

No, naltrexone is not addictive and does not cause physical dependence.

Can naltrexone be used during pregnancy?

Naltrexone should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Discuss with your healthcare provider.

What happens if I use opioids after stopping naltrexone?

Your sensitivity to opioids may be increased after stopping naltrexone, raising the risk of overdose even with small doses.

How long do I need to take naltrexone?

The duration of treatment varies. Many people take naltrexone for several months to a year, depending on individual needs and response.

Does naltrexone help with cravings for alcohol?

Yes, naltrexone can help reduce cravings and the rewarding effects of alcohol, supporting abstinence.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.