Mecasermin injection (mecasermin) — Uses, Dosage, Side Effects & Safety

Drug class: Recombinant human insulin-like growth factor-1 (rhIGF-1)

Overview

Mecasermin injection is a prescription medicine used to treat growth failure in children and adolescents who have severe primary insulin-like growth factor-1 (IGF-1) deficiency or who have developed antibodies to growth hormone and are not responsive to standard growth hormone therapy. It is not indicated for use in children with secondary forms of IGF-1 deficiency, such as those caused by growth hormone deficiency, malnutrition, hypothyroidism, or chronic treatment with glucocorticoids. Mecasermin is a synthetic form of human IGF-1, a hormone that helps promote normal growth and development in bones and tissues. By replacing or supplementing the natural IGF-1 in the body, Mecasermin helps stimulate growth in children whose bodies cannot produce enough IGF-1 on their own. Key points: Mecasermin must be given by subcutaneous injection, usually twice daily, and should always be administered shortly before or after a meal or snack to reduce the risk of low blood sugar (hypoglycemia). Regular monitoring and follow-up with your healthcare provider are essential during treatment.

Frequently Asked Questions about Mecasermin injection

What is Mecasermin injection used for?

Mecasermin is used to treat growth failure in children with severe primary IGF-1 deficiency or those who are unresponsive to growth hormone therapy.

How should Mecasermin be administered?

It should be injected subcutaneously, usually twice daily, shortly before or after a meal or snack to reduce the risk of hypoglycemia.

What are the most common side effects?

The most common side effects are low blood sugar, headache, increased tonsil size, ear infections, and mild injection site reactions.

What should I do if my child misses a dose?

Give the missed dose as soon as possible with a meal or snack. If it is almost time for the next dose, skip the missed dose. Do not double up doses.

Can Mecasermin be used in adults?

No, Mecasermin is not approved for use in adults. Its safety and effectiveness have not been established in this population.

What precautions should be taken during treatment?

Monitor for signs of hypoglycemia, increased intracranial pressure, and abnormal growths. Regular follow-up with your healthcare provider is essential.

Are there any foods or activities to avoid?

Avoid skipping meals or snacks around dosing times, and avoid activities that require alertness if you experience symptoms of low blood sugar.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.