Loncastuximab tesirine — Uses, Dosage, Side Effects & Safety

Drug class: Antineoplastic agent; Antibody-drug conjugate (ADC)

Overview

Loncastuximab tesirine is a prescription medicine used to treat adults with certain types of large B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL), that has returned or has not responded to other treatments. It is typically used when at least two other systemic therapies have failed. This medication is an antibody-drug conjugate, which means it combines a targeted antibody with a chemotherapy agent. The antibody part attaches to a protein (CD19) found on the surface of lymphoma cells, delivering the chemotherapy directly to the cancer cells and helping to limit damage to healthy cells. Key points for patients: Loncastuximab tesirine is given as an intravenous infusion by a healthcare professional, usually every three weeks. It is important to attend all scheduled appointments and report any side effects to your doctor promptly. This medication can cause serious side effects, so regular monitoring is required.

Therapeutic uses

  • Diffuse large B-cell lymphoma (DLBCL)
  • High-grade B-cell lymphoma
  • Primary mediastinal large B-cell lymphoma

Common side effects

  • Myelosuppression
  • Edema
  • Fatigue
  • Nausea
  • Increased liver enzymes
  • Rash
  • Peripheral neuropathy

Frequently Asked Questions about Loncastuximab tesirine

What is loncastuximab tesirine used for?

It is used to treat adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) and other large B-cell lymphomas after at least two prior therapies.

How is loncastuximab tesirine given?

It is given as an intravenous (IV) infusion by a healthcare professional, usually every three weeks.

What are the most common side effects?

Common side effects include fatigue, swelling, nausea, rash, and low blood counts.

Can I take loncastuximab tesirine if I am pregnant?

No. This medication can harm an unborn baby. Use effective contraception during treatment and for several months after the last dose.

Are there any special precautions I should take?

Avoid live vaccines, inform your doctor of all other medications, and report any signs of infection or unusual symptoms promptly.

Is loncastuximab tesirine available in Australia?

Yes, it is available in Australia under the brand name Zynlonta.

What should I do if I miss a dose?

Contact your healthcare provider to reschedule as soon as possible. Do not try to self-administer the medication.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.