Letermovir (letermovir) — Uses, Dosage, Side Effects & Safety

Drug class: Antiviral (Cytomegalovirus DNA terminase complex inhibitor)

Overview

Letermovir is an antiviral medication used to prevent cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell transplant (HSCT) and are CMV-seropositive. CMV is a common virus that can cause serious complications in people with weakened immune systems, such as transplant recipients. Letermovir works by blocking a key enzyme (the CMV DNA terminase complex) that the virus needs to multiply, helping to reduce the risk of CMV infection after a transplant. It is not used to treat active CMV infection, but rather to prevent it. Key points for patients: Letermovir is usually started shortly after your transplant and is taken for a set period (typically up to 100 days). It is important to take this medication exactly as prescribed and to report any unusual symptoms to your healthcare provider.

Frequently Asked Questions about Letermovir

What is letermovir used for?

Letermovir is used to prevent cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell transplant and are CMV-seropositive.

How does letermovir work?

Letermovir blocks the CMV DNA terminase complex, an enzyme essential for viral replication, thereby preventing the virus from multiplying in the body.

Can letermovir be used to treat active CMV infection?

No, letermovir is not indicated for the treatment of active CMV infection. It is only approved for CMV prophylaxis in certain transplant patients.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double up doses.

Are there any foods or drinks I should avoid while taking letermovir?

Avoid grapefruit juice, as it may increase the risk of side effects. Otherwise, letermovir can be taken with or without food.

Is letermovir safe during pregnancy or breastfeeding?

The safety of letermovir in pregnancy and breastfeeding is not established. Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

What are the most serious side effects of letermovir?

Serious side effects include severe allergic reactions, liver problems, and drug interactions that may cause muscle breakdown or heart rhythm changes. Seek immediate medical attention if you experience these.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.