Larotrectinib (larotrectinib) — Uses, Dosage, Side Effects & Safety
Drug class: Selective TRK (tropomyosin receptor kinase) inhibitor; Antineoplastic agent
Overview
Larotrectinib is a targeted cancer medicine used to treat solid tumors that have a specific genetic change known as an NTRK gene fusion. This gene fusion can occur in many types of cancers, both in adults and children. Larotrectinib is prescribed when the tumor has this gene fusion and has either spread (metastasized), cannot be removed by surgery, or has not responded to other treatments. Larotrectinib works by blocking the activity of TRK proteins produced by the abnormal NTRK gene. By inhibiting these proteins, the medicine can slow or stop the growth of cancer cells. It is not chemotherapy, but a type of precision medicine that targets a specific genetic abnormality. Key points for patients: Before starting larotrectinib, your doctor will confirm that your tumor has the NTRK gene fusion. Regular monitoring is required during treatment. Let your healthcare provider know about all other medicines you take and any side effects you experience.
Therapeutic uses
- Solid tumors with neurotrophic tyrosine receptor kinase (NTRK) gene fusion
- Locally advanced solid tumors with NTRK gene fusion
- Metastatic solid tumors with NTRK gene fusion
- Solid tumors with NTRK gene fusion that have progressed following prior treatment or have no satisfactory alternative treatment options
Common side effects
- Fatigue
- Nausea
- Vomiting
- Dizziness
- Increased liver enzymes
- Anemia
- Neurological disorders
Frequently Asked Questions about Larotrectinib
What types of cancer is larotrectinib used for?
Larotrectinib is used to treat solid tumors with an NTRK gene fusion, regardless of the tumor's original location. This includes certain rare cancers in both adults and children.
How will I know if larotrectinib is working?
Your doctor will monitor your response through imaging tests and clinical assessments. Tumor shrinkage or stabilization may indicate effectiveness.
Can I take larotrectinib if I am pregnant or breastfeeding?
No, larotrectinib may harm an unborn baby. Effective contraception is required during treatment and for at least 1 week after the last dose. Breastfeeding is not recommended during treatment.
What should I do if I experience severe side effects?
Contact your healthcare provider immediately if you experience serious side effects such as jaundice, severe abdominal pain, or signs of an allergic reaction.
Are there any foods or medicines I should avoid while taking larotrectinib?
Avoid grapefruit products and medicines that strongly affect CYP3A4 enzymes. Always check with your doctor before starting new medications.
How long will I need to take larotrectinib?
You will continue taking larotrectinib as long as it is effective and side effects are manageable, or until your doctor advises stopping.
Is larotrectinib a form of chemotherapy?
No, larotrectinib is a targeted therapy, not traditional chemotherapy. It specifically targets cancer cells with an NTRK gene fusion.
Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.