Larazotide acetate — Uses, Dosage, Side Effects & Safety

Drug class: Tight junction regulator (anti-inflammatory peptide)

Overview

Larazotide acetate is a medication used to help manage symptoms of celiac disease in adults who continue to experience symptoms despite following a strict gluten-free diet. It works by regulating the tight junctions in the gut lining, which helps reduce the passage of gluten peptides that can trigger inflammation and symptoms in sensitive individuals. This medicine is not a substitute for a gluten-free diet but may be used as an additional therapy to help control symptoms such as abdominal pain, bloating, and diarrhea. Patients should continue to avoid gluten while taking larazotide acetate. Key points for patients: Always take larazotide acetate as prescribed, continue your gluten-free diet, and report any new or worsening symptoms to your healthcare provider.

Therapeutic uses

  • Celiac disease
  • Inflammatory bowel disease
  • Type 1 diabetes mellitus
  • Non-alcoholic steatohepatitis

For related Larazotide acetate guidance, compare Celiac Disease: Symptoms, Causes, Diagnosis, and Treatment.

Common side effects

  • Abdominal pain
  • Nausea
  • Diarrhea
  • Headache
  • Fatigue
  • Upper respiratory tract infection

Frequently Asked Questions about Larazotide acetate

What is larazotide acetate used for?

Larazotide acetate is used as an adjunct treatment for adults with celiac disease who continue to have symptoms despite following a strict gluten-free diet.

How does larazotide acetate work?

It works by regulating the tight junctions in the intestinal lining, reducing the passage of gluten peptides that can trigger inflammation in celiac disease.

Can I stop my gluten-free diet while taking larazotide acetate?

No. Larazotide acetate is not a substitute for a gluten-free diet. You must continue to avoid gluten while taking this medication.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once.

Is larazotide acetate safe during pregnancy or breastfeeding?

Safety in pregnancy and breastfeeding has not been established. Consult your healthcare provider before use.

Can children take larazotide acetate?

Larazotide acetate is not recommended for children under 18 years, as safety and efficacy have not been established in this age group.

What are the most common side effects?

Common side effects include headache, nausea, abdominal pain, bloating, and diarrhea. Most are mild and temporary.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.