Krystexxa (Pegloticase) (Pegloticase) — Uses, Dosage, Side Effects & Safety
Drug class: Urate Oxidase Enzyme (Uricolytic Agent)
Overview
Krystexxa (Pegloticase) is a prescription medication used to treat chronic gout in adults who have not responded to other uric acid-lowering treatments. It is especially helpful for people with severe, treatment-resistant gout, sometimes called refractory gout. Krystexxa works by breaking down uric acid in the body, converting it into a harmless substance called allantoin, which is then easily eliminated by the kidneys. This helps reduce uric acid levels and can dissolve gout crystals, relieving pain and swelling in joints. Key points: Krystexxa is given by intravenous infusion, usually every two weeks, in a healthcare setting. It is not used for mild gout or for people who can control their uric acid with other medications. Serious allergic reactions can occur, so close monitoring is required during and after each infusion.
Therapeutic uses
- Chronic refractory gout
- Severe chronic gout
- Gout not controlled by conventional therapies
Common side effects
- Infusion reactions
- Gout flares
- Nausea
- Bruising
- Anaphylaxis
- Chest pain
- Shortness of breath
- Congestive heart failure
Frequently Asked Questions about Krystexxa (Pegloticase)
What is Krystexxa used for?
Krystexxa is used to treat chronic gout in adults who have not responded to other uric acid-lowering treatments. It is not for mild gout or for people who can control their uric acid with other medications.
How is Krystexxa administered?
Krystexxa is given as an intravenous infusion by a healthcare professional, usually every two weeks. It is not taken by mouth or self-administered.
What are the most common side effects of Krystexxa?
Common side effects include gout flares, nausea, bruising or pain at the injection site, and headache. Serious allergic reactions can also occur.
Can Krystexxa be used in children?
No, Krystexxa is not approved for use in children. Its safety and effectiveness in pediatric patients have not been established.
What should I do if I miss a dose?
Contact your healthcare provider to reschedule your missed infusion. Do not try to make up for a missed dose on your own.
Are there any foods or medications I should avoid while on Krystexxa?
Avoid other uric acid-lowering medications during treatment. Limit alcohol and high-purine foods, as these can worsen gout.
What are the signs of a serious allergic reaction to Krystexxa?
Signs include difficulty breathing, swelling of the face or throat, severe rash, chest pain, or fainting. Seek emergency medical attention if these occur.
Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.